6 Supplements that are a WASTE of Money $$$

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6 Supplements that are a WASTE of Money $$ - Thomas DeLauer
1) BCAAs (instead, fast or use keto to boost leucine preservation)

Leucine & Insulin

In pancreatic beta cells, leucine acutely stimulates insulin secretion by serving as both metabolic fuel and allosteric* activator of glutamate dehydrogenase to enhance glutaminolysis

Leucine regulates insulin secretion by modulating adrenergic α2 receptors through the mTOR pathway - it increases mTOR

In other words, it regulates protein synthesis by activating mTOR in pancreatic beta cells that secrete insulin

Leucine & Insulin

Study - Journal of Diabetes

This study was conducted on 1205 subjects, aged ≥20 years, who were followed-up for a mean of 2.3 years

Dietary intake of BCAAs, including valine, leucine, and isoleucine, was determined and hyperinsulinemia, β-cell dysfunction, insulin resistance (IR), and insulin insensitivity were determined

The mean (± SD) age and BCAA intake of participants (43% male) at baseline were 42.7 years and 13.8 ± 5.1 g/day, respectively

https://www.ncbi.nlm.nih.gov/pubmed/29281182

Insulin & Glucagon

Blood-glucose level begins to drop several hours after a meal, leading to a decrease in insulin secretion and a rise in glucagon secretion

Glucagon is secreted by the alpha cells of the pancreas in response to a low blood-sugar level in the fasting state - Insulin signals the fed state, glucagon signals the starved state

It serves to mobilize glycogen stores when there is no dietary intake of glucose - the main target organ of glucagon is the liver

In addition, glucagon stimulates gluconeogenesis in the liver

Ketones

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373635/#B6

2) Arginine - instead use Citrulline Malate

Citrulline is an amino acid that’s converted to L-arginine in the body, during the urea cycle and alongside L-ornithine

Supplementing with citrulline is actually a more effective way to raise arginine levels and enhance nitric oxide (NO) production in the body, rather than supplementing with arginine itself

Citrulline works better than arginine because it’s converted to L-arginine in the kidneys and increases the level of L-arginine in blood plasma

L-arginine is then readily available to feed into the nitric oxide synthase (NOS) pathway of NO production

Arginine is converted into NO, and increases blood flow and nutrient delivery to working muscles

3) Casein Protein or Beef Protein (instead use pea or whey isolate) Sunwarrior

Casein

Because casein digests so slowly, natural morphine-like substances in casein known as casomorphins, act like opiates in the body as they enter the bloodstream

Casein’s slow digestion rate also puts great strain on the digestive system

https://digitalcommons.molloy.edu/bio_ug_etd/1/

Beef

Beef protein powder isn’t actually made from cow meat, but is actually derived from the throwaway parts of a cow - comes from parts and pieces such as hooves, bones, skin, connective tissue, joints, hide, ligaments, ears, etc.

4) Weight Gainers - Instead just add calories through extra Omega 3 (doesn't store as easily)

If you are eating excessive amounts of DHA or EPA, these fatty acids are more likely to be incorporated into phospholipid bilayers than adipose tissue

The abundance of EPA and DHA in human subcutaneous adipose tissue is low, typically less than 0.2 for EPA and up to 1.0 mol% for DHA

Function

Omega-3s play important roles throughout the body as structural components of cell membranes

5) CLA (get it from animal sources)

Conjugated linoleic acid (CLA) is a naturally occurring trans fatty acid made from omega-6 essential fatty acids in the rumens or guts of pastured ruminants such as cows, goats, and sheep

Conjugated linoleic acids are polyunsaturated fatty acids containing both cis- and trans- bonds as well as double bonds The CLA cis-9,trans-11 is mostly found in foods, whereas trans-10,cis-12 is found in supplements

6) Cheap Testosterone Boosters (use boron)

Testosterone is made by the testes through a complex series of biochemical reactions – which convert cholesterol into testosterone (the adrenal glands also produce some testosterone)

Testosterone molecules are then secreted directly into the bloodstream – where many of them soon bind to other molecules known as sex hormone binding globulin, or SHBG

Boron

There we also significant decreases in E2, which dropped from 42.33 pg/mL to 25.81 pg/mL - the significant decrease in the men’s plasma E2 after 1 week of boron supplementation suggests a higher rate of conversion of total testosterone to free testosterone

http://phypha.ir/ppj/article-1-724-en.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/

https://keithwoodford.wordpress.com/2010/02/20/russian-breakthrough-unravels-bcm7-mysteries/

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