8 Side Effects of the Ketogenic Diet + How to Reverse Them
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8 Side Effects of the Ketogenic Diet + How to Reverse Them - Thomas DeLauer
Skin Health - Skin dries out with dehydration (Fix with Collagen)
A study published in the International Journal of Molecular Sciences looked at the effects of collagen peptides on skin epidermal moisturization after ultraviolet B irradiation-induced skin dehydration
Hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB.
Oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group.
Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue
The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group.
In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP
In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging
https://www.sciencedirect.com/science/article/pii/S1047847717301302
https://pubs.acs.org/doi/10.1021/jp2025768
https://www.ncbi.nlm.nih.gov/pubmed/30423867
Fatigue - Mag ATP
Gluconeogenesis increases on keto, demanding more ATP
ATP (adenosine triphosphate), the main source of energy in cells, must be bound to a magnesium ion in order to be biologically active - what is called ATP is often actually Mg-ATP
Loss of Anaerobic Power
The bulk of ATP for anaerobic exercise comes from glycolysis - the glycolytic process requires that muscle cells breakdown glycogen to glucose via the glycogen phosphorylase pathway
One possible mechanism for reduced anaerobic capacity may be attributed to the LCD-induced keto-acidosis, which was reflected in the present study by reduction of blood pH.
It is well established that anaerobic glycolysis is limited by acidosis via inhibition of the rate limiting enzyme, phosphofructokinase
PFK-1 catalyzes the important "committed" step of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520927/
Headaches
Dehydration
When the body is dehydrated, the brain can temporarily contract or shrink from fluid loss - this mechanism causes the brain to pull away from the skull, causing pain and resulting in a dehydration headache.
Once rehydrated, the brain plumps up and returns to its normal state, relieving the headache.
Also believed that blood vessels in the head may actually narrow in an attempt to regulate body fluid levels - this would make it harder for oxygen and blood to get to the brain, a headache results
https://www.ncbi.nlm.nih.gov/pubmed/20336685
Believed that a keto diet would attenuate migraines due to ketones being able to counteract the neuroinflammation involved in migraines
https://www.ncbi.nlm.nih.gov/pubmed/28527061
Per The Journal of Headache and Pain:
Migraineurs were found and enrolled in a dietician clinical setting. All clinical data were recorded before the diet initiation and, blind to neurologist, subjects were divided in two subgroups: KD and SD followers. After a one month period of diet, patients were re-evaluated for comparisons.
Headache frequency and drug consumption was reduced during the observation period, but only in KD group. Responder rates in KD group (52 subjects) were higher than 90% in terms of attack frequency and drug consumption in the month of observation, while SD group (56 subjects) has no effect.
Responder rate: 90% of those in the KD group saw reductions in migraines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620251/
Muscle Stiffness (Omega 6 Related)
Constipation
Dehydration & electrolyte deficiency is also a cause of constipation and is a problem people on the keto diet face.
Our stools are largely composed of water - 75% of the feces is composed of water, while only 25% is attributed to solids
Keto Breath
The liver breaks down acetone - the smell can vary, but it usually has a fruity (like the smell of rotten apples) smell – usually likened to the smell of nail varnish remover (acetone is a chemical in nail polish remover)
Keto Rash - Neutrophilic Infiltration
Ketone bodies are thought to accumulate around blood vessels, leading to a predominantly neutrophilic inflammation
The ketones subsequently enter the cells, leading to alterations in intracytoplasmic cellular processes [note: “intracytoplasmic” = inside the cytoplasm, which is part of the inside of a cell]
https://www.ncbi.nlm.nih.gov/pubmed/12652193
Видео 8 Side Effects of the Ketogenic Diet + How to Reverse Them канала Thomas DeLauer
Check out Perfect Keto's Collagen and use my $5 gift card AND get free shipping: http://perfectketo.com/td5offcollagen
My Website: http://ThomasDeLauer.com
8 Side Effects of the Ketogenic Diet + How to Reverse Them - Thomas DeLauer
Skin Health - Skin dries out with dehydration (Fix with Collagen)
A study published in the International Journal of Molecular Sciences looked at the effects of collagen peptides on skin epidermal moisturization after ultraviolet B irradiation-induced skin dehydration
Hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB.
Oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group.
Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue
The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group.
In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP
In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging
https://www.sciencedirect.com/science/article/pii/S1047847717301302
https://pubs.acs.org/doi/10.1021/jp2025768
https://www.ncbi.nlm.nih.gov/pubmed/30423867
Fatigue - Mag ATP
Gluconeogenesis increases on keto, demanding more ATP
ATP (adenosine triphosphate), the main source of energy in cells, must be bound to a magnesium ion in order to be biologically active - what is called ATP is often actually Mg-ATP
Loss of Anaerobic Power
The bulk of ATP for anaerobic exercise comes from glycolysis - the glycolytic process requires that muscle cells breakdown glycogen to glucose via the glycogen phosphorylase pathway
One possible mechanism for reduced anaerobic capacity may be attributed to the LCD-induced keto-acidosis, which was reflected in the present study by reduction of blood pH.
It is well established that anaerobic glycolysis is limited by acidosis via inhibition of the rate limiting enzyme, phosphofructokinase
PFK-1 catalyzes the important "committed" step of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520927/
Headaches
Dehydration
When the body is dehydrated, the brain can temporarily contract or shrink from fluid loss - this mechanism causes the brain to pull away from the skull, causing pain and resulting in a dehydration headache.
Once rehydrated, the brain plumps up and returns to its normal state, relieving the headache.
Also believed that blood vessels in the head may actually narrow in an attempt to regulate body fluid levels - this would make it harder for oxygen and blood to get to the brain, a headache results
https://www.ncbi.nlm.nih.gov/pubmed/20336685
Believed that a keto diet would attenuate migraines due to ketones being able to counteract the neuroinflammation involved in migraines
https://www.ncbi.nlm.nih.gov/pubmed/28527061
Per The Journal of Headache and Pain:
Migraineurs were found and enrolled in a dietician clinical setting. All clinical data were recorded before the diet initiation and, blind to neurologist, subjects were divided in two subgroups: KD and SD followers. After a one month period of diet, patients were re-evaluated for comparisons.
Headache frequency and drug consumption was reduced during the observation period, but only in KD group. Responder rates in KD group (52 subjects) were higher than 90% in terms of attack frequency and drug consumption in the month of observation, while SD group (56 subjects) has no effect.
Responder rate: 90% of those in the KD group saw reductions in migraines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620251/
Muscle Stiffness (Omega 6 Related)
Constipation
Dehydration & electrolyte deficiency is also a cause of constipation and is a problem people on the keto diet face.
Our stools are largely composed of water - 75% of the feces is composed of water, while only 25% is attributed to solids
Keto Breath
The liver breaks down acetone - the smell can vary, but it usually has a fruity (like the smell of rotten apples) smell – usually likened to the smell of nail varnish remover (acetone is a chemical in nail polish remover)
Keto Rash - Neutrophilic Infiltration
Ketone bodies are thought to accumulate around blood vessels, leading to a predominantly neutrophilic inflammation
The ketones subsequently enter the cells, leading to alterations in intracytoplasmic cellular processes [note: “intracytoplasmic” = inside the cytoplasm, which is part of the inside of a cell]
https://www.ncbi.nlm.nih.gov/pubmed/12652193
Видео 8 Side Effects of the Ketogenic Diet + How to Reverse Them канала Thomas DeLauer
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