One Carbon Metabolism | Tetrahydrofolate and the Folate Cycle

Lesson on One Carbon Metabolism, the role of tetrahydrofolate and the folate cycle. Tetrahydrofolate (THF) is derivative of folic acid (Vitamin B9), which is acquired from dietary sources. Tetrahydrofolate (THF) in various forms (N5,N10-methylene THF etc.) acts as a carbon donor, allowing cells to produce nucleic acids, amino acids and methionine and s-adenosyl methionine in the activated methyl cycle.

***Re-uploaded to correct mistake***

Hey guys! In this lesson you will learn about one carbon metabolism, tetrahydrofolate and its role in producing various cellular products needed for purine and pyrimidine synthesis. You will also learn which dietary sources contain folic acid (folate), how folate is processed to tetrahydrofolate, and you will also learn the enzymes of the pathway. The anti-cancer medications known as methotrexate and 5-fluorouracil and their enzyme targets will also be discussed. Finally, you will also learn how the one carbon metabolism pathway is connected with the activated methyl cycle and methionine metabolism.

Hope you all find it helpful.
JJ

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Check out some of my other lessons.

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https://www.youtube.com/watch?v=04Wh2E9oNug

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Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk

Gastrulation | Formation of Germ Layers:
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

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JJ

Видео One Carbon Metabolism | Tetrahydrofolate and the Folate Cycle канала JJ Medicine