[瘦而康3]脫醣促細胞自噬，燒脂還肌體青春。太複雜？答﹕好簡單，你看看脫醣燒脂這種健康生活的總框架，了解知、行、目標之間的因果關係，你就會清清楚楚。(詳細科學論據見影片下雜誌。)20201014

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[註1]
DON的成份和劑量

DON是用來抑制「麩醯胺酸 glutamine」的虊物
藥名: DON prodrug, dubbed JHU083
成分﹕6-diazo-5-oxo-L-norleucine
詳見以下論文。

抑制麩醯胺酸-治大腸癌、淋巴癌和皮膚癌(黑色素瘤)[老鼠實驗], September 2019
https://www.sciencedaily.com/releases/2019/11/191108155450.htm
Glutamine-blocking drug slows tumor growth and strengthens anti-tumor response

服用DON的劑量
A 60–70% reduction in tumour growth was observed when DON was administered at 0.5 mg/kg once or twice per week. In comparison, a near complete resolution of the brain tumour was achieved when 1.0 mg/kg of DON was administered with the same schedule, as seen with bioluminescent imaging. These results are significant because no other clinical or pre-clinical study using DON considered a KD-R(指「脫醣燒脂+節食」食療) as a method for protecting the host from toxicity.
詳見以下論文。

抑制麩醯胺酸-治腦癌[老鼠實驗], May 2019
Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541653/

DON的藥效
6-diazo-5-oxo-L-norleucine (DON) is a glutamine antagonist that was initially isolated from a Streptomyces broth in 1956. DON blocks multiple glutaminases, thus restricting key metabolites needed for glutaminolysis and the synthesis of nucleotides and proteins. The anti-tumour efficacy of DON was confirmed in different tumour models, and in humans with various cancers.(這是以上論文的選段)
[註2]
高壓氧治療
全港首間醫院提供高壓氧治療 33醫護人員海外受訓
https://www3.ha.org.hk/ehaslink/issue99/tc/news-03-tc.html
若你或親友認真想用Thomas Seyfried的脫糖燒脂等五管齊下療法，當然要通過肯做這療法的醫生去排期。若輪候太久，可考慮去深圳做，乃至更遠；網上找得到。
[註3]
酮運睡斷 by Naomi Whittel
脫醣燒脂的健康功效，主要在於啟發身體的自噬機制(autophagy)，即選擇性吃掉各部位日久退化的病細胞，等如當燃料燒掉，然後調動幹細胞再生新細胞去補充。不過，沒有足夠運動和睡眠，自噬機制調動不起來。故酮(keto)、運(exercise)、睡(sleep)、斷(fasting)﹐缺一不可。
10 minutes, May 2019
The Anti-Aging MIRACLE - 4 Tips to Activate Autophagy
https://youtu.be/AMbad5X9voY
以上短片說明中，有些解釋，抄貼如下﹕
1. The Keto Diet: When on the ketogenic diet our bodies will begin to induce autophagy in a way similar to that which occurs while fasting. As your body shifts from being glucose-dependent to fat-dependent, autophagy allows the body to maintain energy homeostasis and create benefits from the starvation as opposed to detriments.
2. Intermittent Fasting: While we fast, our cells enter a phase where they literally digest themselves to recycle and reuse the good while discarding the bad. If we constantly eat throughout the day, it doesn’t give our cells a chance to repair and clean up the waste and toxins that have accumulated.
3. Exercise: Exercise creates microtears and inflamed muscle tissue which activates the autophagic process to repair and optimize the muscles. However, acute exercise may do more damage than good, so exercise in moderation is more efficient.
4. Sleeping. The sleep is the easiest and most enjoyable way of activating autophagy, simply because it requires no sacrifice or effort. However, miraculous things are going on inside our bodies that we are not even aware of. This is one of my favorite ways to activate autophagy :)
[註4]
什麼是細胞自噬？
即細胞回春。
Autophagy is the system that recycle unnecessary, aged, damaged or dysfunctional components within cells. The targets of autophagy are long-lived proteins and malfunctioning organelles(細胞器官). Autophagy serves as a dynamic recycling system that produces new building blocks and energy for cellular renovation and homeostasis(自體平衡).
文獻 November 2011
Autophagy: renovation of cells and tissues
https://pubmed.ncbi.nlm.nih.gov/22078875/ (此頁撮要之右上角有FULL TEXT LINK)
選段
All living organisms undergo continuous renovation. In humans, cells and intracellular components are constantly remodeled and recycled. This is, in part, in order to replace old components with fresh, better-quality ones. ... Such “cellular renovation” requires synthesis of new components but also degradation of pre-existing materials, which can serve as building blocks.
細胞自噬是把老舊、殘缺、失效、多餘、乃至害群的細胞零部件(即細胞器官organalles)回收再造，造出新的、鮮活、利群的細胞器官，令細胞回復青春。
[註5]
細胞自噬、幹細胞、回春
論文 March 2020
Autophagy and Stem Cells: Self-Eating for Self-Renewal
https://www.frontiersin.org/articles/10.3389/fcell.2020.00138/full
選段節譯
最健康的細胞是剛從靜態幹細胞經啟動和分化為不同身體器官的更新細胞。這就是stem cell 的quiescence, activation, differentiation, and self-renewal. 細胞自噬應用於幹細胞時，就促成肌體回春的基本機制。
[註6]斷食和生酮飲食促細胞自噬
報導 August 2018
Autophagy: What You Need to Know
https://www.healthline.com/health/autophagy#diet
選段﹕

“Fasting is the most effective way to trigger autophagy,” explains Petre.(see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/ ) (老鼠實驗)
斷食，[因為使身體很快就脫了醣]，最能促細胞自噬。(有文獻 August 2010，連結如上)

“Ketosis, a diet high in fat and low in carbs brings the same benefits of fasting without fasting,” she adds. “By not overwhelming the body with an external load, it gives the body a break to focus on its own health and repair.”
生酮免卻身體燒醣的苦差，輕鬆燒脂(即生酮ketones)，則可集中自強自癒。
補看﹕
「Tsui Hon Kwong」頻道的連結﹕
https://www.youtube.com/playlist?list=PLK6KkwC86SGEq0EdSUY9LfSlltl9PrLct

Видео [瘦而康3]脫醣促細胞自噬，燒脂還肌體青春。太複雜？答﹕好簡單，你看看脫醣燒脂這種健康生活的總框架，了解知、行、目標之間的因果關係，你就會清清楚楚。(詳細科學論據見影片下雜誌。)20201014 канала Tsui Hon Kwong