Против старения, рака, сахарного диабета, жирового гепатоза, мигрени, СРК и нейропатии

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ТАЙМКОДЫ:
0:00 Что такое мелатонин
3:11 Последствия понижения и повышения мелатонина
6:45 Болезни, от которых помогает мелатонин
14:35 Как проверить уровень мелатонина?
15:19 При каких состояниях уместно принимать мелатонин
16:37 Мелатонин против старения
17:33 Как безопасно принимать мелатонин
18:56 Как повысить мелатонин без приема добавок
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Источники:
https://www.ncbi.nlm.nih.gov/books/NBK550972/
https://pubmed.ncbi.nlm.nih.gov/36829823/
1 Conclusions: Melatonin showed a beneficial prophylactic role in migraine,
https://pubmed.ncbi.nlm.nih.gov/36445912/

2 Conclusion: This meta-analysis provides evidence for the use of exogenous melatonin in IBS patients to ameliorate overall IBS severity, IBS pain severity, and quality of life.
https://pubmed.ncbi.nlm.nih.gov/36257872/
3 Conclusion: Nonetheless, in the majority of cases, these diabetes-induced biochemical and histological alterations were reversed when melatonin was administered. It is worth noting that the administration of melatonin ameliorates the neuropathy caused by diabetes. Melatonin exerts these neuroprotective effects via various anti-oxidant, anti-inflammatory, and other mechanisms.

https://www.frontiersin.org/articles/10.3389/fphar.2022.984499/full
4 Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence
Although some limitations have been found regarding variability in the study design, the findings here summarized display the potential role of melatonin in ameliorating the development of liver fibrosis and its possible progression to liver cirrhosis and hepatocarcinoma.
https://onlinelibrary.wiley.com/doi/10.1002/jcp.30735
5 Melatonin effectiveness in amelioration of oxidative stress and strengthening of antioxidant defense system: Findings from a systematic review and dose-response meta-analysis of controlled clinical trials
The dosages of melatonin varied between 3 and 400 mg/day!!!!!
Conclusion: Results of the current meta-analysis showed that melatonin supplementation had a significant impact on attenuating oxidative stress and enhancing antioxidant performance. Melatonin supplementation could be suggested as a safe complementary approach to amelioration of chronic diseases.
6 Conclusions: We found that adjunctive melatonin supplementation can significantly improve the periodontal status after non-surgical treatment
https://pubmed.ncbi.nlm.nih.gov/35290552/
7 Our results showed that melatonin administration significantly reduced insulin levels and homeostasis model assessment of insulin resistance (HOMA-IR), and increased the quantitative insulin sensitivity check index (QUICKI).
https://pubmed.ncbi.nlm.nih.gov/34496412/
Conclusions: Our results showed that melatonin supplementation was useful for reducing diabetes parameters when compared to placebo.
https://pubmed.ncbi.nlm.nih.gov/34229264/
8 Melatonin could reduce the progress of NAFLD.
https://pubmed.ncbi.nlm.nih.gov/34058202/
9 The findings of this meta-analysis revealed that melatonin administration in humans as a cardioprotective agent attenuated heart dysfunction with a favorable effect on the LVEF
https://pubmed.ncbi.nlm.nih.gov/34055929/
10 Meta-analysis of MMSE score suggested that melatonin is effective in treatment for mild stage of AD.
https://pubmed.ncbi.nlm.nih.gov/33957167/
11 Exogenous melatonin reduced levels of inflammatory markers
https://pubmed.ncbi.nlm.nih.gov/33581247/
12 Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo-controlled trial
https://pubmed.ncbi.nlm.nih.gov/26352863/
Методы диагностики уровня мелатонина
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142625/
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