Curing Alzheimer's Disease is hard. But WE can do something..

Since it's first discovery by Alois Alzheimer, numerous scientists tried to find a cure for Alzheimer's disease. However, finding an Alzheimer's disease cure is difficult. But why is that? And is there anything we can do to lower the risk of getting Alzheimer's disease? Let's talk about the science Alzheimer's disease!

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0:00-1:13 Discovery of Alzheimer's Disease
1:13-3:17 How does Alzheimer's Disease Work?
3:17-7:11 Why is it difficult to Treat Alzheimer's Disease?
7:11-11:27 Can WE prevent Alzheimer's Disease?

Over 50 million people suffer from Alzheimer's disease worldwide. Alzheimer's disease primarily affects the brain. In early stages of Alzheimer's disease, patients become forgetful. Later symptoms include anxiety or severe dementia. Alois Alzheimer discovered that the brains of Alzheimer's disease patients have lost many brain cells. Furthermore, he described amyloid plaques and neurofibrillary tangles. Amyloid plaques and neurofibrillary tangles are toxic to brain cells and, therefore, cause Alzheimer's disease.
For decades, many scientists tried to cure Alzheimer's disease. Finding sufficient treatments or cures for Alzheimer's disease is challenging as first plaques occur decades before the patient exhibits first symptoms. As a consequence, current clinical trials for Alzheimer's disease need to be conducted for years which is not feasible. In the future of Alzheimer's disease, biomarker will likely solve this issue.
Current treatmens for Alzheimer's disease include acetylcholinesterase inhibitors and NMDA receptor antagonists. A few weeks ago, the FDA approved aducanumab which is an antibody treatment against Alzheimer's disease.
Some of us have specific gene variations (APP, PS1, PS2) which cause Alzheimer's disease. But the majority of AD cases is impacted by our environment. Studies have shown that we can lower the risk of getting Alzheimer's disease by having low cholesterol levels and blood pressure. Aerobic exercise and mental training has also demonstrated a beneficial effect in preventing Alzheimer's disease (brain plasticity). Sleep is also crucial as it can activate glial cells which partially remove amyloid plaques. Let's hope that there will be a cure for Alzheimer's disease one day!

For your reading:
Sharma, Piyoosh, et al. "Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies." Progress in neurobiology 174 (2019): 53-89.
Novak, Petr, et al. "ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer’s disease." Nature Aging 1.6 (2021): 521-534.

Images:
Some pictures were derived from Servier Medical Art by Servier. You can find over 3000 free medical images here: https://smart.servier.com/
Alzheimers disease brain by Hersenbank, CC BY-SA 3.0
Drama masks by By Yuvika Koul, CC BY-SA 3.0
Brain Cells by GerryShaw, CC-BY-SA 3.0

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About Clemens Steinek:
CLEMENS STEINEK is a PhD student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany.

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