DEFECTS IN DNA REPAIR, DNA repair genes & Associated Cancers
In this short tutorial, i have described how defects in DNA repair results in cancer and various DNA repair genes which are involved in the repair of damaged DNA.
****Follow me*****
http://ilovepathology.com/
Twitter : https://twitter.com/VijayPatho
https://twitter.com/ilovepathology2
Facebook: https://www.facebook.com/ilovepathology/
Defects in DNA repair& Cancer
DNA damage is ubiquitous
DNA damage is not the same as mutation though it can lead to mutation
DNA damage is a chemical alteration ( can be corrected)
Mutation is a change in the sequence of base pairs ( cannot be corrected )
If any kind of DNA damage is likely to lead to a mutation, we call it genotoxic
There are Mechanisms to repair the types of DNA damage
The Effective DNA repair is the backbone of cancer free survival
Genome instability is an Important hallmark of cancer
INSTABILITY: could be point mutations, trinucleotide repeat expansions and contractions, gene duplications, deletions, and inversions, to large-scale chromosome changes including translocations and whole chromosome gains and losses.
DNA repair systems play critical roles in genome stabilization
Defects in DNA repair pathways contribute to specific instabilities
Erroneous DNA repair leads to mutations or chromosomal aberrations
The Genes for DNA repair
Individuals with inherited defects in DNA repair genes are at increased risk of developing cancer.
Base Excision Pathway (BER):MDB4,Colorectal Ovary Multiple myeloma
NER Pathway:XPC, Bladder Skin Cancer
Direct reversal of Damage:MGMT,Colon Gastric Glioblastoma
Mismatch excision repair (MMR):MSH 6Colorectal
Non Homologous End joining: XRCC5, lung
Homologous recombination: BRCA 1,Breast Ovary Gastric
-~-~~-~~~-~~-~-
Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
https://www.youtube.com/watch?v=LXaO59IqQm8
-~-~~-~~~-~~-~-
Видео DEFECTS IN DNA REPAIR, DNA repair genes & Associated Cancers канала ilovepathology
****Follow me*****
http://ilovepathology.com/
Twitter : https://twitter.com/VijayPatho
https://twitter.com/ilovepathology2
Facebook: https://www.facebook.com/ilovepathology/
Defects in DNA repair& Cancer
DNA damage is ubiquitous
DNA damage is not the same as mutation though it can lead to mutation
DNA damage is a chemical alteration ( can be corrected)
Mutation is a change in the sequence of base pairs ( cannot be corrected )
If any kind of DNA damage is likely to lead to a mutation, we call it genotoxic
There are Mechanisms to repair the types of DNA damage
The Effective DNA repair is the backbone of cancer free survival
Genome instability is an Important hallmark of cancer
INSTABILITY: could be point mutations, trinucleotide repeat expansions and contractions, gene duplications, deletions, and inversions, to large-scale chromosome changes including translocations and whole chromosome gains and losses.
DNA repair systems play critical roles in genome stabilization
Defects in DNA repair pathways contribute to specific instabilities
Erroneous DNA repair leads to mutations or chromosomal aberrations
The Genes for DNA repair
Individuals with inherited defects in DNA repair genes are at increased risk of developing cancer.
Base Excision Pathway (BER):MDB4,Colorectal Ovary Multiple myeloma
NER Pathway:XPC, Bladder Skin Cancer
Direct reversal of Damage:MGMT,Colon Gastric Glioblastoma
Mismatch excision repair (MMR):MSH 6Colorectal
Non Homologous End joining: XRCC5, lung
Homologous recombination: BRCA 1,Breast Ovary Gastric
-~-~~-~~~-~~-~-
Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
https://www.youtube.com/watch?v=LXaO59IqQm8
-~-~~-~~~-~~-~-
Видео DEFECTS IN DNA REPAIR, DNA repair genes & Associated Cancers канала ilovepathology
Показать
Комментарии отсутствуют
Информация о видео
Другие видео канала
Mechanisms of DNA Damage and RepairTUMOR SUPPRESSOR GENES: Retinoblastoma Gene, Knudson's Two Hit Hypothesis.WARBURG EFFECT: Hallmark of CANCER. What, Why & How?What happens when your DNA is damaged? - Monica MenesiniHALLMARKS OF CANCER 1: Protooncogenes, Oncogenes & OncoproteinsDNA Repair: The Body's D.I.Y. | Ed Miller | TEDxBrumOncogenetics - Mechanism of Cancer (tumor suppressor genes and oncogenes)APOPTOSIS PART 1: Definition, Causes & Mechanism/PathwaysSteve Jackson Lecture | EACR DNA Damage Responses and Cancer Virtual Conference | 20 May 2020NEOPLASIA: BASICS-1: Nomenclature: Benign, Malignant, Mixed tumors, teratoma,Hamartoma, choristomaDisease associated with DNA repair mechanismsCHEMICAL CARCINOGENESIS & Ames testp53 gene: The Guardian of the genome. functions, regulation and inactivationMENDEL LECTURES / Paul Modrich / Mechanisms in DNA Mismatch Repair / 18.5.2017DNA repair 1 | Biomolecules | MCAT | Khan AcademyThe Age of Superhumans - Gene Editing Through CRISPR & AIGlioma Brain Tumors: Surgical Therapies and Current Genetic StudiesMutation and DNA repair mechanism animationMary Beckerle (University of Utah) Part 1: Adhesion, Signaling and CancerTumor Suppressor Genes - p53, pten, p21, pRB