Microscopy contest video winner: Reconstituted ovary with in vitro derived oocytes by Matthew Lowe

Generated by: Matthew Lowe, a graduate student in the lab of Amander Clark, Ph.D.
Instrument: Zeiss LSM 880
Magnification: 20x

A ‘reconstituted ovary’ is produced by combining embryonic mouse ovarian tissue with lab-generated germ-cell-like mouse cells – germ cells have the ability to become eggs or sperm. This generates an environment that supports the development of oocytes, which are the cells in the ovary that can create an egg and then an embryo, if fertilized. The developing oocytes (teal) can be seen in supportive nests of granulosa cells (red). This technique can be used to explore causes of infertility or potentially provide a new avenue for researching methods to treat infertility by generating oocytes from patient-derived tissue.

Видео Microscopy contest video winner: Reconstituted ovary with in vitro derived oocytes by Matthew Lowe канала UCLA Broad Stem Cell Research Center