G protein-coupled receptors (GPCRs) as Drug Targets - Medicinal Chemistry 1.17
Drugs that target G-protein coupled receptors or GPCR account for near 30% of the global market share of therapeutic drugs. The high interest and large market share are because of how important GPCRs are in many diseases. Right now, there are over 2000 different mutations in 55 GPCR genes that have been characterized and linked to over 60 human diseases. Based on how those mutations can change the functions of GPCRs, mutations can be divided into gain-of-function mutations and loss-of-function mutations.
--About me--
I am a computational chemist in the pharmaceutical industry. I created the Mole Man Chem channel to explain some basic medicinal and biochemistry concepts because I believe the best way to relearn a concept is through teaching.
Feel free to email me with any questions at molemanchem@gmail.com
--Video lists--
Medicinal chemistry playlist: https://www.youtube.com/watch?v=SNYb7E9oWO4&list=PLK7JMguNBXJOefOP5WFy9AUIsKReOD91I&t=0s
Drug discovery explained playlist: https://www.youtube.com/watch?v=0rMcD-_dGDI&list=PLK7JMguNBXJOBMkSsluR2926rtYLfRO7m
0:00 Overview
0:57 GPCR
4:52 GPCR mutations
8:25 GPCR mutation-caused disease treatment
Видео G protein-coupled receptors (GPCRs) as Drug Targets - Medicinal Chemistry 1.17 канала Daniel S.
--About me--
I am a computational chemist in the pharmaceutical industry. I created the Mole Man Chem channel to explain some basic medicinal and biochemistry concepts because I believe the best way to relearn a concept is through teaching.
Feel free to email me with any questions at molemanchem@gmail.com
--Video lists--
Medicinal chemistry playlist: https://www.youtube.com/watch?v=SNYb7E9oWO4&list=PLK7JMguNBXJOefOP5WFy9AUIsKReOD91I&t=0s
Drug discovery explained playlist: https://www.youtube.com/watch?v=0rMcD-_dGDI&list=PLK7JMguNBXJOBMkSsluR2926rtYLfRO7m
0:00 Overview
0:57 GPCR
4:52 GPCR mutations
8:25 GPCR mutation-caused disease treatment
Видео G protein-coupled receptors (GPCRs) as Drug Targets - Medicinal Chemistry 1.17 канала Daniel S.
Показать
Комментарии отсутствуют
Информация о видео
Другие видео канала
Lock-and-key, Induced Fit, Conformational Selection, and Protein Dynamics - Medicinal Chemistry 1.3Receptors as Drug Targets (An Intro) - Medicinal Chemistry 1.16First Nobel Prize in Chemistry 1901 - Jacobus H. van't HoffEnzyme Inhibitors (Reversibility and Inhibition Mode) - Medicinal Chemistry 1.12Tertiary Structure of Protein - Medicinal Chemistry 1.710 Types of Drug Discovery ScientistsProteins as Drug Targets: Microtubule Inhibitors - Medicinal Chemistry 1.9Quaternary Structure of Protein - Medicinal Chemistry 1.8Conformational Selection Model vs. Induced Fit Model - Medicinal Chemistry 1.10Ion Channels as Drug Targets - Medicinal Chemistry 1.18How did Pfizer/BioNTech win the COVID-19 vaccine race?Amino Acids Classification and Protein Primary Structure - Medicinal Chemistry 1.4What is medicinal chemistry - Medicinal Chemistry 0.0Enzymes as Drug Targets (An Intro) - Medicinal Chemistry 1.11Drug Targets: DNA, RNA and Protein - Medicinal Chemistry 1.2Orthosteric Drugs And Allosteric Drugs - Medicinal Chemistry 1.15What Is a Drug, Therapeutic Index, Selective Toxicity - Medicinal Chemistry 1.1Alpha Helix, Protein Secondary Structure - Medicinal Chemistry 1.5Suicide Substrates/Mechanism-based Inhibitors - Medicinal Chemistry 1.14Beta Sheet, Protein Secondary Structure - Medicinal Chemistry 1.6