Everything You Need to Know About a Coronavirus Vaccine | with Prof. Danny Altmann from Imperial

There are some huge questions around the vaccine development programme for Covid-19. When will one be ready? Will it be safe? How long will immunity last? Does it matter which one it is? SPOILER - Yes.

With the insight of Professor of Immunology Danny Altmann from Imperial College London, I delve into the subject and try to answer just about every question you might want to ask.

0:26 What is a vaccine and how do they work?
1:47 Why do we need a vaccine for Covid-19?
3:34 What are the different types of vaccine?
7:59 What are the most common misconceptions about a vaccine?
9:13 What does a good vaccine look like?
12:48 Who are the leading contenders?
13:43 How does the clinical trials process work?
16:28 What are the risks of rushing a vaccine?
19:14 And what about those waning antibodies?
21:42 How long can we expect a vaccine to last?
22:13 When will a vaccine be ready?
23:58 What about viral mutation?
25:26 Will it be safe?
27:14 If it’s legit, should you take it?
29:21 Conclusion

REFERENCES

RNA vaccine information
https://www.phgfoundation.org/briefing/rna-vaccines

Recombinant Vector Vaccine information
https://www.publichealth.org/public-awareness/understanding-vaccines/vaccines-work/

BMJ - Sputnik
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30402-1/fulltext

Dr Eric Topol - leading candidates:
https://twitter.com/erictopol/status/1308785711802327041?s=21

ADE, or Antibody Dependent Enhancement
https://www.nature.com/articles/s41564-020-00789-5
https://www.nature.com/articles/d41587-020-00016-w

TH2 Lung pathology,
https://twitter.com/daltmann10/status/1300125798461067265?s=21

FDA under approvals pressure, The Guardian
https://www.theguardian.com/world/2020/aug/30/fda-covid-19-vaccine-fast-track

Waning Antibodies
https://uk.reuters.com/article/us-health-coronavirus-antibodies-vaccine/swiftly-waning-covid-19-immunity-poses-vaccination-challenge-idUKKCN24F261

Dr Eric Topol - slow genetic drift
https://twitter.com/erictopol/status/1308228580275437568?s=21

Vaccine Refuseniks
https://www.theguardian.com/world/2020/sep/24/a-fifth-of-people-likely-to-refuse-covid-vaccine-uk-survey-finds
https://news.gallup.com/poll/317018/one-three-americans-not-covid-vaccine.aspx

Oxford/AZ trial hold
https://www.theguardian.com/world/2020/sep/09/oxford-university-astrazeneca-covid-vaccine-trial-put-on-hold-due-to-adverse-reaction-in-participant

Oxford/AZ trial restart
https://www.npr.org/sections/coronavirus-live-updates/2020/09/12/912281381/astrazeneca-resumes-its-covid-19-vaccine-trials-in-the-u-k?t=1600266138711

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