COVID-19 Insights: Remdesivir Mechanism of Action

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. Remdesivir Mechanism of Action

Note: Remdesivir is an adenine analog and not uracil. I taught it as a Uracil analog.

MERS-COV peaks in humans between 7-10 days after the onset of symptoms. This gives a good chance to use Remdesivir.
Early therapy with Remdesivir will help reduce the virus load and the damage due to the immune response.
https://www.nature.com/articles/s41467-019-13940-6
https://www.ncbi.nlm.nih.gov/pubmed/28659436
Mechanism of action
https://microbenotes.com/remdesivir/

Adenosine nucleotide analog

SARS-COV and MERS-COV pathophysiology
https://www.mdpi.com/1999-4915/11/1/59/htm

Clinical Trial of Remdesivir to Treat COVID-19 Begins
https://www.niaid.nih.gov/news-events/nih-clinical-trial-remdesivir-treat-covid-19-begins

Improvement observed in 68% of the patients
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2007016?articleTools=true

Remdesivir clinical trials
https://www.gilead.com/purpose/advancing-global-health/covid-19/remdesivir-clinical-trials
Inconclusive yet hopeful results
https://www.biospace.com/article/data-from-gilead-s-compassionate-use-of-remdesivir-for-covid-19-looks-promising/

Another study finds the drug with high death rate and more side effects
https://www.ft.com/content/0a4872d1-4cac-4040-846f-ce32daa09d99 ...

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Видео COVID-19 Insights: Remdesivir Mechanism of Action канала Drbeen Medical Lectures