Parietal Cell of gastric gland

In this video, we will be discussing the parietal cell of the gastric gland. We will discuss its importance and short.
Parietal cells are specialized cells found in the gastric glands of the stomach. Here are ten lines describing the parietal cells and their functions:
Parietal cells are located in the gastric glands of the stomach, particularly in the body and fundus regions.
They secrete hydrochloric acid (HCl) into the stomach lumen, contributing to the acidic environment of the stomach.
Parietal cells also produce intrinsic factor, a glycoprotein necessary for the absorption of vitamin B12 in the small intestine.
The secretion of hydrochloric acid by parietal cells helps in the digestion of food, particularly proteins, by denaturing them and activating pepsinogen to pepsin.
Parietal cells play a crucial role in the defense against pathogens by creating an acidic environment that inhibits the growth of bacteria and other microorganisms.
These cells possess numerous mitochondria, as they require high energy levels to actively transport hydrogen ions (protons) into the stomach lumen.
Parietal cell function is regulated by various factors, including gastrin, histamine, and acetylcholine, which stimulate acid secretion.
Proton pump inhibitors (PPIs) are medications that specifically target and inhibit the activity of the proton pump in parietal cells, reducing acid secretion.
Parietal cell dysfunction can lead to conditions such as achlorhydria (absence of stomach acid production) or hyperchlorhydria (excessive stomach acid production).
Overall, the function of parietal cells is essential for the maintenance of gastric pH, digestion of proteins, absorption of vitamin B12, and defense against pathogens in the stomach.
It's important to note that while I strive to provide accurate and up-to-date information, medical knowledge and terminologies may evolve over time. Therefore, it's always a good idea to consult medical professionals or trusted sources for specific medical advice or the most recent research.

Видео Parietal Cell of gastric gland канала easy humananatomy