COVID-19 Pandemic Update 101: T Cell Immunity vs. Antibodies & Prior Exposure to Other Coronaviruses

The relationship between antibodies for the novel coronavirus (SARS-CoV-2) and immunity, vaccine efficacy, and spread of COVID-19 has received significant attention. Dr. Seheult is back to illustrate why T cells have received less attention than antibodies, but may be more important to long term immunity from COVID-19. Dr. Seheult also discusses how previous infections with common coronaviruses may provide some immunity to SARS-CoV-2, and the hypothesis that reducing the inoculum (initial dose) of SARS-CoV-2 might result in less symptom severity (This video was recorded August 10, 2020).

LINKS / REFERENCES:

5-Minute Sharable Video About At-Home Rapid Tests | https://www.medcram.com/courses/antigen-highlights

Johns Hopkins Tracker | https://coronavirus.jhu.edu/map.html

Worldometer | https://www.worldometers.info/coronavirus/

CNBC | https://www.cnbc.com/2020/08/07/coronavirus-vaccine-dr-fauci-says-chances-of-it-being-highly-effective-is-not-great.html

Clinical Infectious Diseases | https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa644/5848814

Cell | https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3#secsectitle0070

Washington Post | https://www.washingtonpost.com/health/2020/08/08/asymptomatic-coronavirus-covid/

Nature | https://www.nature.com/articles/s41591-020-0965-6

Journal of General Internal Medicine (Reducing inoculum) | https://link.springer.com/article/10.1007/s11606-020-06067-8

CDC | https://www.cdc.gov/mmwr/volumes/69/wr/mm6919e1.htm

NPR | https://www.npr.org/sections/health-shots/2020/07/24/894148860/without-a-vaccine-researchers-say-herd-immunity-may-never-be-achieved

New York Times | https://www.nytimes.com/2018/09/21/well/live/immunity-vaccines-measles-mumps-tetanus-vaccination.html
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Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
Associate Professor at the University of California, Riverside School of Medicine

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Video Produced by Kyle Allred

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