Metabolism of Drug (Part 01)- Introduction (HINDI) By Solution Pharmacy
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Drug metabolism is the term used to describe the biotransformation of pharmaceutical substances in the body so that they can be eliminated more easily. The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there.
The purpose of metabolism in the body is usually to change the chemical structure of the substance, to increase the ease with which it can be excreted from the body.
Drugs are metabolized through various reactions including:
(1) Oxidation
(2) Reduction
(3) Hydrolysis
(4) Hydration
(5) Conjugation
(6) Condensation
(7) Isomerization
There are often two phases of drug metabolism.
(1) Phase I: Non-synthetic reactions such as cleavage (e.g. oxidation, reduction, hydrolysis), formation or modification of a function group.
(2) Phase II: Synthetic reactions such as conjugation with an endogenous substance (e.g. sulfate, glycine, glucuronic acid).
The most common and important enzyme group involved in the Phase I metabolism of drugs is the cytochrome P450 (CYP450) superfamily of enzymes. This group of enzymes acts as a catalyst for the oxidation of many drugs. It can, in turn, also be induced or inhibited by many drugs and other substances. As a result, the metabolism of some drugs is affected by the presence of other substances. This is what is known as a drug interaction.
Some of the important enzymes in this family include:
CYP1A2
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP3A4
Description Credit- https://www.news-medical.net/health/Drug-Metabolism.aspx
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Видео Metabolism of Drug (Part 01)- Introduction (HINDI) By Solution Pharmacy канала Solution- Pharmacy
https://youtu.be/cE5MAt0J6hs Using Mobile https://youtu.be/ntzXKi2pA5U
Free model question paper for pharmacology 01 (All units) –
https://drive.google.com/drive/folders/1d61HhxtPwkK3TqY2ZD45z_shGayyG3xO?usp=sharing
Free Pharmacology- 1 notes (made by students) –
https://drive.google.com/open?id=1PRaNYy7_a60FCIpDzKTIK4gxOLhBclFQ
Drug metabolism is the term used to describe the biotransformation of pharmaceutical substances in the body so that they can be eliminated more easily. The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there.
The purpose of metabolism in the body is usually to change the chemical structure of the substance, to increase the ease with which it can be excreted from the body.
Drugs are metabolized through various reactions including:
(1) Oxidation
(2) Reduction
(3) Hydrolysis
(4) Hydration
(5) Conjugation
(6) Condensation
(7) Isomerization
There are often two phases of drug metabolism.
(1) Phase I: Non-synthetic reactions such as cleavage (e.g. oxidation, reduction, hydrolysis), formation or modification of a function group.
(2) Phase II: Synthetic reactions such as conjugation with an endogenous substance (e.g. sulfate, glycine, glucuronic acid).
The most common and important enzyme group involved in the Phase I metabolism of drugs is the cytochrome P450 (CYP450) superfamily of enzymes. This group of enzymes acts as a catalyst for the oxidation of many drugs. It can, in turn, also be induced or inhibited by many drugs and other substances. As a result, the metabolism of some drugs is affected by the presence of other substances. This is what is known as a drug interaction.
Some of the important enzymes in this family include:
CYP1A2
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP3A4
Description Credit- https://www.news-medical.net/health/Drug-Metabolism.aspx
Get in touch with the solution by just clicking following links-
Facebook Page- https://www.facebook.com/pharmavideo/
Facebook Group- https://www.facebook.com/groups/solutionpharamcy
Instagram- https://www.instagram.com/solutionpharmacy/
Mail Us for Free Pharmacology Materials- solutionpharmacy@gmail.com
LinkedIn- http://linkedin.com/in/pushpendrakpatel
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