Bioavailability and Bioavailability Curve - General Pharmacology (HINDI) By Solution Pharmacy
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Bioavailability and factors affecting bioavailability- https://youtu.be/FZQ5WCiUEKE
Bioavailability refers to the extent and rate at which the active moiety (drug or metabolite) enters systemic circulation, thereby accessing the site of action.
Bioavailability of a drug is largely determined by the properties of the dosage form, which depend partly on its design and manufacture. Differences in bioavailability among formulations of a given drug can have clinical significance; thus, knowing whether drug formulations are equivalent is essential. Bioavailability is usually assessed by determining the area under the plasma concentration-time curve The most reliable measure of a drug’s bioavailability is AUC. AUC is directly proportional to the total amount of unchanged drug that reaches systemic circulation. Drug products may be considered bioequivalent in extent and rate of absorption if their plasma concentration curves are essentially superimposable. Plasma drug concentration increases with the extent of absorption; the maximum (peak) plasma concentration is reached when the drug elimination rate equals absorption rate.
Physicochemical properties of the drug and its excipients that determine its dissolution in the intestinal lumen and its absorption across the intestinal wall.
Decomposition of the drug in the lumen.
pH and perfusion of the small intestine.
Surface and time were available for absorption.
Competing reactions in the lumen (for example of the drug with food).
Hepatic first-pass effect.
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Видео Bioavailability and Bioavailability Curve - General Pharmacology (HINDI) By Solution Pharmacy канала Solution- Pharmacy
https://youtu.be/cE5MAt0J6hs Using Mobile https://youtu.be/ntzXKi2pA5U
Free model question paper for pharmacology 01 (All units) –
https://drive.google.com/drive/folders/1d61HhxtPwkK3TqY2ZD45z_shGayyG3xO?usp=sharing
Free Pharmacology- 1 notes (made by students) –
https://drive.google.com/open?id=1PRaNYy7_a60FCIpDzKTIK4gxOLhBclFQ
Download full PDF notes- https://www.facebook.com/download/preview/1433524666781006
Bioavailability and factors affecting bioavailability- https://youtu.be/FZQ5WCiUEKE
Bioavailability refers to the extent and rate at which the active moiety (drug or metabolite) enters systemic circulation, thereby accessing the site of action.
Bioavailability of a drug is largely determined by the properties of the dosage form, which depend partly on its design and manufacture. Differences in bioavailability among formulations of a given drug can have clinical significance; thus, knowing whether drug formulations are equivalent is essential. Bioavailability is usually assessed by determining the area under the plasma concentration-time curve The most reliable measure of a drug’s bioavailability is AUC. AUC is directly proportional to the total amount of unchanged drug that reaches systemic circulation. Drug products may be considered bioequivalent in extent and rate of absorption if their plasma concentration curves are essentially superimposable. Plasma drug concentration increases with the extent of absorption; the maximum (peak) plasma concentration is reached when the drug elimination rate equals absorption rate.
Physicochemical properties of the drug and its excipients that determine its dissolution in the intestinal lumen and its absorption across the intestinal wall.
Decomposition of the drug in the lumen.
pH and perfusion of the small intestine.
Surface and time were available for absorption.
Competing reactions in the lumen (for example of the drug with food).
Hepatic first-pass effect.
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Facebook Page- https://www.facebook.com/pharmavideo/
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Видео Bioavailability and Bioavailability Curve - General Pharmacology (HINDI) By Solution Pharmacy канала Solution- Pharmacy
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