COVID-19 Insights: Sickle Cell, Thalassemia, Hemophilia

SARS-COV-2 and blood disorders

https://hemophilianewstoday.com/information-about-covid-19-for-hemophilia-patients/

What are inhibitors?
https://www.feiba.com/us/patient/hemophilia-inhibitors
For example factors VIII or IX clotting factors for hemophilia
Are patients with blood disorders at a higher risk?
Some patients with hemophilia may develop inhibitors and doctors may prescribe them immunosuppressants. These are medicines that suppress the immune system. They may, therefore, make patients more susceptible to infections including SARS-CoV-2.
Plasma therapy is safe from SARS-COV-2 pathogen transmission. Statement by HFA
https://www.hemophiliafed.org/news-stories/2020/03/plasma-protein-therapeutics-association-updated-statement-regarding-coronavirus/

PPTA Statement
https://www.pptaglobal.org/media-and-information/ppta-statements/1055-2019-novel-coronavirus-2019-ncov-and-plasma-protein-therapies

WORLD FEDERATION OF HEMOPHILIA RECOMMENDATIONS FOR HEMOPHILIA PATIENTS
https://www.hemophiliafed.org/news-stories/2020/03/world-federation-of-hemophilia-recommendations-for-hemophilia-patients/

Pandemic and hemoglobin disorders
Sickle cell anemia
Cell sickling in the hypoxic and acidic environment leading to the acute chest syndrome. Plus carboxyamide is mild immunosuppressant that may results in additional risk.
https://www.thalassemia.org/boduw/wp-content/uploads/2020/03/COVID-19-pandemic-and-haemoglobin-disorders_V2.pdf?__cf_chl_jschl_tk__=764a85856edbb5277a06a1c3c87ca9b7e0b49e6d-1589051509-0-Abe-j8o6Rzg3h049qyF_ddqkWDqhgebQLjG1o8390qmQu6_dFzpNjey2hVgV0BQa2RbQRVOBExkb9VdjMTT1bTg_zcvSbhOIZrh98-HkeIZW9jLyJOaUNTX-QVPrFoqJ8SCATKdUcLmnWRWyp2E5kU6n2GPg8fip_6XFf18uLY9fM2Ef45L65yjHhAyE_0aSTwF0B99q5Ivk0JV_WWZAGHZgp4vcbt_2IHqbinjwkUwxBw9D4zzGvdD7Npcc8nxL7ucH79x2BU_D8CXQ2kLMezf11xtbN4DrVQk-zl3XCcEn4jcwKtI6tKGRbcmcRqmgOsq_RrN8T2OEGQUxBhPtgv_ty6oNERuTgpapoO3nzjckPlFqE-UUuIdLLF13WfNxjQ

Hemophilia and COVID-19
von Willebrand Disease and Hemophilia A
https://news.wfh.org/world-federation-of-hemophilia-statement-update-to-covid-19/
Hypercoagulopathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156948/

Desmopressin (DDAVP)
https://en.wikipedia.org/wiki/Desmopressin

G6PD deficiency and COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166036/

How I treat vWF disease
https://ashpublications.org/blood/article/97/7/1915/53343/How-I-treat-patients-with-von-Willebrand-disease

Видео COVID-19 Insights: Sickle Cell, Thalassemia, Hemophilia канала Drbeen Medical Lectures