Professor Sarah Bohndiek - Seeing early cancer in a new light

Title: Seeing early cancer in a new light
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Abstract: The dynamic cellular ecosystem of a growing tumour mass requires a vascular network to obtain oxygen and nutrients, as well as to remove metabolic waste products. Early in their development, tumours stimulate new blood vessel growth through a range of mechanisms to meet this need, leading to marked differences between normal and tumour tissue that could be exploited for early cancer detection.

The structure and function of the tumour vasculature can be revealed using optics, thanks to the strong absorption of light by oxy- and deoxy-haemoglobin. To extract quantitative biomarkers such as haemoglobin concentration and oxygenation from optical images, we combine novel spectral imaging methods with advanced computational analysis and biophysical modelling, applied in both preclinical cancer models and early phase clinical trials in patients. In this talk, I will focus on one aspect of these studies, applying multi- and hyper-spectral imaging during endoscopic surveillance of the gastrointestinal tract.

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About the speaker: Professor Sarah Bohndiek completed her PhD in Radiation Physics at University College London in 2008 and then worked in both the UK (at Cambridge) and the USA (at Stanford) as a postdoctoral fellow in molecular imaging. Since 2013, she has been a Group Leader at the University of Cambridge, where she is jointly appointed as a Professor of Biomedical Physics in the Department of Physics and the Cancer Research UK Cambridge Institute.

Her interdisciplinary team, the VISIONLab develop novel imaging approaches that can be applied to understand the role of the tumour microenvironment in cancer progression. The VISIONLab is also active in translating their findings into clinical trials. She was recently awarded the CRUK Future Leaders in Cancer Research Prize and SPIE Early Career Achievement Award in recognition of her interdisciplinary research innovation.

Professor Bohndiek also takes an active role in teaching and mentoring the next generation of scientists. She has received the MSCA Award for Nurturing Research Talent for her active involvement in public engagement and interdisciplinary research training throughout her career.

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