Gluconeogenesis from lactate, glycerol, propionyl coA and glucogenic amino acids
Gluconeogenesis
Synthesis of glucose from non carbohydrates precursors
Precursors/ substrates includes
1. Lactate
2. Glycerol
3. Propionyl coA
4. Glucogenic amino acids
Not exactly reversal of glycolysis
3 irreversible steps in glycolysis reversed by 4 important enzymes
1. Pyruvate carboxylase
2. Phosphoenolpyruvate carboxykinase
3. Fructose 1,6 bisphosphatase
4. Glucose 6 phosphatase
Gluconeogenesis
Site - cytosol/ mitochondria
Mostly in Liver and to some extent in renal cortex
1. Important source of glucose during starvation after depletion of glycogen ( after 18 hrs)
2. Important source of energy for brain and RBCs
Energy utilized - 6 ATP/ glucose synthesis
Regulation
1. Induction and repression
Insulin represses pyruvate carboxylase
Glucagon induces
2. Covalent modifications
By phosphorylation and dephosphorylation of enzymes by hormones
Glucagon phosphorylate enzymes and activates
3. Allosteric activation
By acetyl coA
And inhibition by F2,6 BP
Видео Gluconeogenesis from lactate, glycerol, propionyl coA and glucogenic amino acids канала Biochemistry by Dr Rajesh Jambhulkar
Synthesis of glucose from non carbohydrates precursors
Precursors/ substrates includes
1. Lactate
2. Glycerol
3. Propionyl coA
4. Glucogenic amino acids
Not exactly reversal of glycolysis
3 irreversible steps in glycolysis reversed by 4 important enzymes
1. Pyruvate carboxylase
2. Phosphoenolpyruvate carboxykinase
3. Fructose 1,6 bisphosphatase
4. Glucose 6 phosphatase
Gluconeogenesis
Site - cytosol/ mitochondria
Mostly in Liver and to some extent in renal cortex
1. Important source of glucose during starvation after depletion of glycogen ( after 18 hrs)
2. Important source of energy for brain and RBCs
Energy utilized - 6 ATP/ glucose synthesis
Regulation
1. Induction and repression
Insulin represses pyruvate carboxylase
Glucagon induces
2. Covalent modifications
By phosphorylation and dephosphorylation of enzymes by hormones
Glucagon phosphorylate enzymes and activates
3. Allosteric activation
By acetyl coA
And inhibition by F2,6 BP
Видео Gluconeogenesis from lactate, glycerol, propionyl coA and glucogenic amino acids канала Biochemistry by Dr Rajesh Jambhulkar
Показать
Комментарии отсутствуют
Информация о видео
16 декабря 2018 г. 7:16:36
00:20:35
Другие видео канала
![Glycogen metabolism- Glycogenesis and Glycogenolysis](https://i.ytimg.com/vi/2oCxmqVwvrI/default.jpg)
![Hexose Monophosphate Shunt (HMP Shunt)](https://i.ytimg.com/vi/mh14uCMizp0/default.jpg)
![TCA Cycle or Krebs Cycle](https://i.ytimg.com/vi/-ptxPt4ojLk/default.jpg)
![Metabolism | Gluconeogenesis](https://i.ytimg.com/vi/YpV96faQOZc/default.jpg)
![Regulation of blood glucose level](https://i.ytimg.com/vi/n91BckD0mMU/default.jpg)
![Gluconeogenesis Pathway Made Simple - BIOCHEMISTERY](https://i.ytimg.com/vi/ydhr0QAyxYg/default.jpg)
![Biotransformation, Detoxification, Metabolism of Xenobiotics](https://i.ytimg.com/vi/Y8dguLjPXaY/default.jpg)
![Glycolysis- Important points, steps, regulation and energetics](https://i.ytimg.com/vi/ZiGE01M_t9c/default.jpg)
![Gluconeogenesis Pathway: Overview, Enzymes, Co-Factors and Precursors](https://i.ytimg.com/vi/2dmr3-kJu_M/default.jpg)
![Metabolism | Regulation of Gluconeogenesis](https://i.ytimg.com/vi/ORIx2WYNWqs/default.jpg)
![Glycogen metabolism Regulation and glycogen storage disorders](https://i.ytimg.com/vi/i_C1Iv6h4-w/default.jpg)
![Carcinogenesis, Oncogenes, Tumor suppressor genes](https://i.ytimg.com/vi/j_tLVIeE8w4/default.jpg)
![Ketone bodies- Synthesis, utilization and clinical significance](https://i.ytimg.com/vi/lSVnpFUxRvk/default.jpg)
![DNA Replication in Eukaryotes- Dr. Rajesh Jambhulkar, MBBS,MD,DNB](https://i.ytimg.com/vi/I7yFxkdza9k/default.jpg)
![Gluconeogenesis metabolic pathway and regulation : Animated medical biochemistry](https://i.ytimg.com/vi/u-WXvNPxqvM/default.jpg)
![Krebs Cycle - Citric Acid Cycle - Cellular Respiration](https://i.ytimg.com/vi/BJaybQFboYc/default.jpg)
![GOUT](https://i.ytimg.com/vi/-Rfy-P_pHpA/default.jpg)
![Urea cycle- site, steps, regulation, energetics and disorders](https://i.ytimg.com/vi/ng8823q42JE/default.jpg)
![Tryptophan metabolism
1. Kynurenine- anthranilate pathway
2. Serotonin Pathway](https://i.ytimg.com/vi/4F6itRpul_g/default.jpg)
![Acid base disorders with case discussion](https://i.ytimg.com/vi/LGgdBODbRfQ/default.jpg)