Does Vitamin D Treat Multiple Sclerosis?

Does Vitamin D Treat Multiple Sclerosis?

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My book, "Resilience in the Face of Multiple Sclerosis" on Amazon: https://www.amazon.com/dp/B07WP7H5LK

Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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An article I wrote about dietary evidence in MS:
http://www.caloriedense.com/ms.html

References:

1Alpha,25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes.: Cytokine. 2009 Mar;45(3):190-7; Almerighi C et al
"Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins"; Talat Islam, W. James Gauderman, Wendy Cozen, and Thomas M. Mack Articles | Neurology July 24, 2007 69:4 381-388

“Gestational Vitamin D and the Risk of Multiple Sclerosis in the Offspring”; Ann Neurol. Jul 2011; 70(1): 30–40. ; Fariba Mirzaei, M.D., MPH, ScD,1,2 Karin B. Michels, ScD, Ph.D.,2,4,7 Kassandra Munger, ScD et al

“Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis.” JAMA. 2006 Dec 20;296(23):2832-8. Munger KL1, Levin LI, Hollis BW, Howard NS, Ascherio A.

"The effect of vitamin D-related interventions on multiple sclerosis relapses: a meta-analysis." Mult Scler. 2013 Oct;19(12):1571-9. James E1, Dobson R, Kuhle J, Baker D, Giovannoni G, Ramagopalan SV.

"1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.”; J Immunol. 2001 Nov 1;167(9):4974-80.; Boonstra A1, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O'Garra A.

“Alteration of T cell subsets and induction of suppressor T cell activity in normal subjects after exposure to sunlight.” J Immunol. 1983 Jul;131(1):171-4; Hersey P, Haran G, Hasic E, Edwards A.

Time-course evaluation and treatment of skin inflammatory immune response after ultraviolet B irradiation; Paz ML, Ferrari A, Weill FS, Leoni J, Maglio DH Cytokine. 2008 Oct; 44(1):70-7.

Characterization of regulatory dendritic cells differentiated from the bone marrow of UV-irradiated mice.
Ng RL, Scott NM, Bisley JL, Lambert MJ, Gorman S, Norval M, Hart PH Immunology. 2013 Dec; 140(4):399-412.

1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression; Schwarz A1, Navid F, Sparwasser T, Clausen BE, Schwarz T; J Invest Dermatol. 2012 Dec;132(12):2762-9.;

Vitamin D as an early predictor of multiple sclerosis activity and progression.
Ascherio A, Munger KL, White R, Köchert K, Simon KC, Polman CH, Freedman MS, Hartung HP, Miller DH, Montalbán X, Edan G, Barkhof F, Pleimes D, Radü EW, Sandbrink R, Kappos L, Pohl C
JAMA Neurol. 2014 Mar; 71(3):306-14.

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study.
Mokry LE, Ross S, Ahmad OS, Forgetta V, Smith GD, Goltzman D, Leong A, Greenwood CM, Thanassoulis G, Richards JB PLoS Med. 2015 Aug; 12(8):e1001866.

MS Sunshine Study: Sun Exposure But Not Vitamin D Is Associated with Multiple Sclerosis Risk in Blacks and Hispanics; Langer-Gould A1, Nutrients. 2018 Feb 27;10(3)

The video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

Видео Does Vitamin D Treat Multiple Sclerosis? канала Dr. Brandon Beaber