Cells dynamically adjust stiffness to optimize morphogensis
Video shows the role of longitudinal stiffness in converting apical constriction to ventral furrow formation.
Left: simulations with zero longitudinal stiffness of mesodermal cells.
Right: simulations with dynamically increasing longitudinal stiffness of central mesodermal cells and decreasing stiffness of peripheral cells.
Model done in CompuCell3D by Abhisha Thayambath from NC State.
Citation:
Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation
JM Gomez, C Bevilacqua, A Thayambath, J-K Heriche, M Leptin, JM Belmonte, R Prevedel
Nature Communications 16: 6473
https://www.nature.com/articles/s41467-025-61702-4
Видео Cells dynamically adjust stiffness to optimize morphogensis канала juliomontibelmonte
Left: simulations with zero longitudinal stiffness of mesodermal cells.
Right: simulations with dynamically increasing longitudinal stiffness of central mesodermal cells and decreasing stiffness of peripheral cells.
Model done in CompuCell3D by Abhisha Thayambath from NC State.
Citation:
Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation
JM Gomez, C Bevilacqua, A Thayambath, J-K Heriche, M Leptin, JM Belmonte, R Prevedel
Nature Communications 16: 6473
https://www.nature.com/articles/s41467-025-61702-4
Видео Cells dynamically adjust stiffness to optimize morphogensis канала juliomontibelmonte
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15 июля 2025 г. 11:22:16
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