Harnessing the power of bacterial factories

New biochemistry dropped. This video goes over a new development in our understanding of how bacteria produce antibiotics. But first, lets go over a little history of how we got here.

Written by April, narrated by Dante & edited by April

Information sources:
+Quinn, Z., et. al. (2017). Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants. Chemical Science
https://doi.org/10.1039/C6SC04265A
+Devine, R., et. al. (2021). Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds. Cell Chemical Biology
https://doi.org/10.1016/j.chembiol.2020.12.011
+Hutchings, M., et. al. (2019). Antibiotics: past, present and future. Current Opinion in Microbiology
https://doi.org/10.1016/j.mib.2019.10.008
+ BBC (2013) Pain, Pus and Poison: The Search for Modern Medicine, episode 2 'Pus'

Media sources:
+ video of petri dishes and soil from Man In The Doorway (1957) retrieved from youtube user AV geeks https://youtu.be/i_Xlkc3B1P4
+molecular animation by Drew Berry, https://wehi.tv link to video https://youtu.be/aV-kI_ep1Rk
+ high throughput screen robots from NCATS NIH youtube channel https://youtu.be/FOp-lX3NY6E
+ moldy fruit from BBC (2013) Pain, Pus and Poison: The Search for Modern Medicine, episode 2 'Pus'
+ ant video by Katja Schulz https://commons.wikimedia.org/wiki/File:Trapijaw_ant_(Odontomachus).webm
+ color liquids in chemistry glassware video from youtube user AV Geeks https://youtu.be/L_oBRC4sCV4

#antibiotics #drugdiscovery #science

Видео Harnessing the power of bacterial factories канала bioZone