Rheumatoid Arthritis| Rheumatoid Arthritis Angiogenesis

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The lock and key that hold the secret to rheumatoid arthritis treatment… coming up next

Molecules identified that are involved in rheumatoid arthritis angiogenesis

Reported in MNT, two protein molecules that fit together as lock and key seem to promote the abnormal formation of blood vessels in joints affected by rheumatoid arthritis, according to researchers at the University of Illinois at Chicago College of Medicine, who found that the substances are present at higher levels in the joints of patients affected by the disease.

Their results are reported in the journal Annals of the Rheumatic Diseases.

"Our results show, for the first time, that these two proteins - a receptor and its corresponding binding protein - play a key role in the progression of rheumatoid arthritis pathology," said Shiva Shahrara, associate professor of rheumatology at UIC.
Rheumatoid arthritis is a chronic autoimmune inflammatory disease in which the body's own defenses attack the tissues lining the joints, causing painful swelling and bone erosion that can ultimately lead to joint deformities.

One of the hallmarks of rheumatoid arthritis is the development of new blood vessels, or angiogenesis, in the joints.

"The swelling of joints is caused by the abnormal migration of a variety of different cell types into the joint," Shahrara said. "And as these cells accumulate, they need to be supplied with oxygen and nutrients, and so angiogenesis accompanies the joint swelling."

Comment: Angiogenesis is an important cause of RA. This research looks promising.

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Видео Rheumatoid Arthritis| Rheumatoid Arthritis Angiogenesis канала Nathan Wei