Sickle cell anemia - Studying inflammation mediated vascular permeability with the Maestro Z system

Learn more: https://www.axionbiosystems.com/applications/cellular-kinetics/barrier-function?utm_campaign=cbw&utm_medium=organic-video&utm_source=youtube&utm_content=sickle-cell-anemia

What you will learn in this 13 minute webinar:
1. Endothelial cells from different vascular beds respond differently to pro- and anti-inflammatory cytokines, as recorded on the Maestro Z platform.

2. Monocyte-induced endothelial permeability is distinct from cytokine-induced permeability, and there may be patient-specific differences from people living with sickle cell anemia.

3. The Maestro Z system provides an effective platform for monitoring changes to cell barrier permeability, label-free and in real-time.
Summary:
In a patient with Sickle Cell Anemia, you can have altered endothelial cell permeability due to the chronic inflammation of the cells that line the blood vessel wall and control transportation. In this webinar, Manu Platt, PhD (Georgia Institute of Technology) discusses how he evaluated the difference in vascular wall permeability in control and sickle cell disease models as recorded on the Maestro live-cell analysis system.

System used:
Maestro Z system for in vitro barrier assay: https://www.axionbiosystems.com/products/systems/maestro-z

Видео Sickle cell anemia - Studying inflammation mediated vascular permeability with the Maestro Z system канала Axion BioSystems