Pediatric epilepsy study on the Maestro multiwell MEA system: Coffee Break Webinar

Axion's multiwell MEA system helps understand drug treatments for pediatric epilepsy.

Learn more: https://www.axionbiosystems.com/applications/neural-activity/neurological-disease

Epilepsy is a devastating neurological disease caused by an imbalance in the electrical signals between the cells of the brain. It affects 1% of newborns and very young children. In children, 1/3 of all cases fail to respond to currently available medication. The primary challenge in the fight against epilepsy is the lack of model systems that effectively mirror what goes wrong in human patients. In this webinar, Dr. Evangelos Kiskinis (Northwestern University), using the Maestro multiwell MEA system, demonstrates how patient-specific neurons in vitro recapitulate the neural firing patterns observed in patient EEGs in vivo. Using this platform Dr. Kiskinis hopes to be able to predict what drug would work best for each patient, removing the trial-and-error approach to epilepsy therapy.

What is a multiwell MEA assay?
Axion’s microelectrode array (MEA), also known as multielectrode array, plates have a grid of tightly spaced electrodes embedded in the culture surface of each well. Electrically active cells, such as neurons, can be cultured over the electrodes. Over time, as the cultures become established, they form cohesive networks and present an electrophysiological profile. The resulting electrical activity, spontaneous or induced firing of neurons, is captured from each electrode on a microsecond timescale providing both temporally and spatially precise data.

Видео Pediatric epilepsy study on the Maestro multiwell MEA system: Coffee Break Webinar канала Axion BioSystems