DTIs (Bivalirudin, Argatroban, Dabigatran) Preview for Medicine & USMLE

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Direct thrombin inhibitors or DTIs inhibit blood clot formation by blocking the actions of thrombin, also known as factor 2. This medication class includes the drugs dabigatran, argatroban, and the drugs that end in the suffix -rudin, like bivalirudin, lepirudin, and hirudin. DTIs are used to prevent blood clots in patients with atrial fibrillation, deep vein thrombosis, and heparin-induced thrombocytopenia.
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