Ephedrine / Phenylephrine Mnemonic for Nursing Pharmacology (NCLEX)

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Ephedrine, pseudoephedrine, and phenylephrine are medications that have different effects depending on their route of administration. When given nasally or orally, they can be used to treat congestion. When used as a decongestant, a potential side effect is rebound nasal congestion, so patients should not take these medications for more than 3-5 days and should taper off the drug slowly. When given through an IV, these drugs act systemically as vasopressors, where they constrict the blood vessels to increase blood pressure. Regardless of the route of administration, side effects to look out for include CNS stimulation, which can present as insomnia, restlessness, agitation, or nervousness. These drugs can also cause uncontrolled hypertension, and should not be given concurrently with other drugs that cause hypertension, or to patients who already have high blood pressure and other cardiovascular conditions.

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