Pharmacology - CANCER DRUGS – CELL CYCLE SPECIFIC AND NONSPECIFIC AGENTS (MADE EASY)

Cancer is generally defined as the uncontrolled growth of abnormal cells in the body. One of the common approaches in treatment of cancer is to use drugs that target fast-dividing cells at different phases of the cell cycle. This pharmacology lecture covers mechanism of action and side effects of cell cycle specifc agents including topoisomerase inhibitors (type I & type II) and microtubule inhibitors (vinca alkaloids & taxanes) as well as cell cycle nonspecfic agents including antitumor antibiotics (anthracyclines), alkylating agents (nitrogen mustards, nitrosoureas, triazines, alkyl sulfonates), platinum coordination complexes, tyrosine kinase inhibitors (targeting BCR-ABL, HER2, PDGF, VEGF, EGF receptors), and monoclonal antibodies. Antineoplastic drugs mentioned include; Irinotecan, Topotecan, Etoposide, Vincristine, Vinblastine, Vinorelbine, Paclitaxel, Docetaxel, Cabazitaxel, Doxorubicin, Daunorubicin, Epirubicin, Idarubicin, Bleomycin, Chlorambucil, Cyclophosphamide, Ifosfamide, Melphalan, Carmustine, Lomustine, Dacarbazine, Temozolomide, Busulfan, Cisplatin, Carboplatin, Oxaliplatin, Imatinib, Dasatinib, Nilotinib, Lapatinib, Sunitinib, Erlotinib, Trastuzumab, Cetuximab, Bevacizumab, and Rituximab.

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Source of image showing one-electron redox cycle of anthracyclines: https://www.hindawi.com/journals/bmri/2013/751913/

Source of image showing Cisplatin activation and DNA damage induction: http://www.scielo.br/scielo.php?pid=S1807-59322018000200317&script=sci_arttext

0:00 Overview
0:47 Topoisomerase Inhibitors
2:13 Microtubule Inhibitors
4:23 Antitumor Antibiotics
6:38 Alkylating Agents
7:44 Platinum Coordination Complexes
8:42 Tyrosine Kinase Inhibitors
10:41 Monoclonal Antibodies
12:14 Side Effects

Видео Pharmacology - CANCER DRUGS – CELL CYCLE SPECIFIC AND NONSPECIFIC AGENTS (MADE EASY) канала Speed Pharmacology