CHAPTER 8 - Enzymes Kinetics, Mechanisms, and Inhibition

HARPER BIOCHEMISTY
CHAPTER 8

This , "Enzymes: Kinetics," from Harper's Illustrated Biochemistry, explores the quantitative study of enzyme-catalysed reaction rates and the influences upon them, such as temperature, pH, and substrate concentration. It discusses how enzyme kinetics is vital for understanding biological processes and is a key tool in the development of drugs that target enzyme activity. Key concepts like Michaelis-Menten kinetics, including the constants Vmax and Km, are explained, alongside the behavior of multimeric enzymes exhibiting cooperativity, described by the Hill equation. The text also differentiates between competitive and noncompetitive enzyme inhibition, outlining their effects on kinetic parameters and their analysis using plots like the Lineweaver-Burk and Dixon plots.

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