Immunoglobulin G (IgG) USMLE Mnemonic

Immunoglobulin G or IgG is the most abundant type of antibody in blood important in fighting off pathogens in infection. After exposure to a new antigen, the production of IgG is delayed or slower than IgM due to the need for class switching to produce IgG. Because of its small size, IgG is the only antibody able to cross the placenta from the mother to the baby, which makes it pathogenic in diseases like erythroblastosis fetalis. IgG antibodies help clear pathogens from our bodies in three main ways. First, IgG can opsonize microbes, marking them for ingestion for phagocytic cells. Second, they can fix complement, activating complement by the classical pathway to kill the pathogen and attract other immune cells to the site. Finally, IgG can directly neutralize microbes or toxins produced to prevent further harm.

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