Immunoglobulin IgM or IgM USMLE Mnemonic Preview

IgM is one of the five major subtypes of antibodies produced by B-cells. IgM is the default or original antibody type produced, and does not require class switching to produce. As such, it is the first and fastest antibody to be made in response to an infection. IgM circulates as a pentamer, which impairs its ability to cross the placenta. However, this pentameric structure makes IgM an excellent fixer of complement, triggering the classical pathway of complement activation.

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