CaAKG - the healthspan extender you need to know about?

Alpha-ketoglutarate (AKG) is a small compound, but plays a big role in our cells. Notably, AKG is a key component in the metabolic pathway, the Krebs Cycle. However, levels of AKG have been shown to decline with age. Delivered as a calcium salt (CaAKG), this recent publication (ref below) shows that AKG can extend healthspan in both male and female mice, and extends lifespan in middle-aged female mice. In this video, I will discuss in more detail what AKG is, the results of this paper and my thoughts.

TIMESTAMPS;
00:00 - Intro
00:56 - What is AKG? Aging connection
04:27 - Study results
08:35 - How/Why AKG has this effect?
10:00 - AKG in humans?
11:00 - Thoughts/Outlook

**reference at 3:42 should be https://doi.org/10.1111/acel.13059 Aging Cell. 2020;19:e13059 !!
REFERENCES;
Paper -- Asadi Shahmirzadi et al., 2020, Cell Metabolism 32, 447–456
September 1, 2020 ª 2020 Published by Elsevier Inc.
https://doi.org/10.1016/j.cmet.2020.08.004
Press Release - https://www.lifespan.io/news/pilot-study-results-suggest-epigenetic-age-reversal/ & https://pdlhealth.com/in-the-news/
Dr Kennedy Lab; https://www.buckinstitute.org/lab/kennedy-lab/
Extends lifespan in C.elegans; Chin, R., Fu, X., Pai, M. et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510, 397–401 (2014). https://doi.org/10.1038/nature13264
Pigs; Oncotarget. 2017; 8:91965-91978. https://doi.org/10.18632/oncotarget.20555
Gut Microbiome - The effects of dietary supplementation with α-ketoglutarate on the intestinal microbiota, metabolic profiles, and ammonia levels in growing pigs
https://doi.org/10.1016/j.anifeedsci.2017.03.017

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Видео CaAKG - the healthspan extender you need to know about? канала The Sheekey Science Show