Tackling Fungi That Cause Lung Disease | A Multiscale Approach

#Lungdiseases caused by fungal species of the Aspergillus genus affect millions of people annually. While many people recover from these infections, in settings of severe underlying disease or immune dysfunction they can often be fatal. Expansion of at-risk patient populations, including those infected by #COVID19 and #influenza, is combining with rapidly increasing rates of antifungal drug resistance to threaten utility of the few available antifungal drugs.

During her talk, Professor Elaine Bignell from the MRC Medical Mycology Centre at the University of Exeter gives us insights into her #research which seeks to understand the mechanisms of how Aspergillus fungi cause lung disease with a view to developing novel diagnostics and antifungal therapies. Her approach integrates infection models which transcend multiple experimental scales to address disease outcomes at the molecular, cellular, tissue, organ and whole animal levels.

Of all microbial pathogens of humans, fungi are the least well studied and understood. The cost of diagnosing and treating fungal infections also has major economic impact. The MRC Centre for Medical Mycology (MRC CMM) enables this group of researchers to utilise and expand its critical mass, promoting pioneering cross-disciplinary research that covers areas of scientific, translational and clinical importance.

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