Dermatologist reviews A313 pommade| Dr Dray

#Dermatologist #DrDray reviews cult #skincare product A313 vitamin A pomade. A313 pomade contains retinyl esters. It is not as strong or effective as the prescription retinoic acid cream tretinoin . It is not as strong or effective as differin. It is not as robust as retinaldehyde or retinol for improvement of wrinkles, fine lines, hyperpigmentation, and photoaging.

Retinyl esters are hydrolyzded to retinol which is then oxidized to retinaldehyde. Retinaldehyde is then oxidized to the skin active form of Vitamin A, retinoic acid. Tretinoin (retin A), tazarotene (tazorac), and adapalene (differin) are skin active forms of vitamin A.

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💜References
Stratigos AJ. The role of topical retinoids in the treatment of photoaging. Drugs 2005; 65: 1061–1072.
Sorg O, Antille C, Kaya G, et al. Retinoids in cosmeceuticals. Dermatol Ther 2006; 19: 289–296.
Pierard-Franchimont C, Castelli D, Cromphaut IV, et al. Tensile properties and contours of aging facial skin. A controlled doubleblind comparative study of the effects of retinol, melibioselactose and their association. Skin Res Technol 1998; 4: 237– 243.
Tucker-Samaras S, Zedayko T, Cole C, et al. A stabilized 0.1% retinol facial moisturizer improves the appearance of photodamaged skin in an eight-week, double-blind, vehiclecontrolled study. J Drugs Dermatol 2009; 8: 932–936.
Ho ET, Trookman NS, Sperber BR, et al. A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. J Drugs Dermatol 2012; 11: 64–69.
Babcock M, Mehta RC, Makino ET. A randomized, double-blind,split-face study comparing the efficacy and tolerability of threeretinol-based products vs. three tretinoin-based products insubjects with moderate to severe facial photodamage. J DrugsDermatol 2015; 14:24–30.
Creidi P, Vienne MP, Ochonisky S, et al. Profilometricevaluation of photodamage after topical retinaldehyde andretinoic acid treatment. J Am Acad Dermatol 1998; 39: 960–965.
Kwon HS, Lee JH, Kim GM, et al. Efficacy and safety ofretinaldehyde 0.1% and 0.05% creams used to treat photoagedskin: a randomized double-blind controlled trial. J CosmetDermatol 2018; 17: 471–476.
Green C, Orchard G, Cerio R, et al. A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing. Clin Exp Dermatol 1998; 23: 162–167.
Lee MS, Lee KH, Sin HS, et al. A newly synthesizedphotostable retinol derivative (retinyl N-formyl aspartamate) forphotodamaged skin: profilometric evaluation of 24-week study. JAm Acad Dermatol 2006; 55: 220–224.
Kim H, Kim N, Jung S, et al. Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial. Br J Dermatol 2010; 162: 497–502.

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