Why do mutant immune cells provide Alzheimer's resilience?

Pathologist Siddhartha Jaiswal discovers a surprising twist to our biology: age-related mutations that increase the risk of blood disease also protect against brain disease.

Jaiswal, author Julia Belk and research associate Jacob Weiss discuss this research, published in Nature Medicine, offering new insight that provides clues to uncovering how to slow the progression of dementia.

Jaiswal’s team will continue their exploration of the subject with support from the Phil and Penny Knight Initiative for Brain Resilience at Wu Tsai Neuro, which is advancing transformative new ideas to promote healthy brain aging and resilience against neurodegenerative diseases.

Read the Nature Medicine publication, Clonal hematopoiesis is associated with protection from Alzheimer’s disease, here: https://www.nature.com/articles/s41591-023-02397-2

Learn more about Jaiswal's Innovation Grant project, Mutant microglia and resilience to Alzheimer’s disease, here: https://neuroscience.stanford.edu/research/funded-research/mutant-microglia-and-resilience-alzheimer-s-disease

Видео Why do mutant immune cells provide Alzheimer's resilience? канала Wu Tsai Neurosciences Institute, Stanford