2025-W4: Volatilomics - bringing small molecules in multi-omics landscape -biomedical investigations

Presenters:
 David Alonso (LECO Corporation)
 Maria Llambrich (IISPV)
 Flavio Franchina (University of Ferrara)
 James Harynuk (University of Alberta)
 Pierre-Hugues Stefanuto (University of Liege)

Description:
The vast collection of metabolites presents in biological systems, i.e. the metabolome, is chemically diverse. In discovery-based, untargeted metabolomics where the goal is to detect and annotate as many metabolites as possible, the use of complementary analytical platforms is extremely important. No single analytical platform is capable of characterizing the degree of chemical diversity present in these types of samples on its own.

This workshop will focus on small volatile molecules fraction, i.e., volatilomics, and their high potential as molecular phenotype descriptors in biological systems. The main step of volatilomics will be covered in this workshop.
1. Understanding the specificity of volatilomics technology
2. the key role of QAQC and the challenges of volatilomics methods
3. the conception of volatilomics workflow from sampling to processing
4. the high potential of multi-platform approaches
5. the high performance of multidimensional chromatography for non-targeted volatilomics, and the 6. the implementation of volatilomics in clinical studies.

Workshop Objectives:
 To illustrate the biological relevance of volatile molecules and their key relationships with phenotypes.
 To highlight the key steps of non-targeted metabolomics research and the specificity of volatilomics workflows.
 To increase awareness of the critical role modern GC-MS and direct MS instrumentation plays in complementary multi-platform metabolomics.
 To address the fundamental requirements of each step of volatilomics workflows, including QA/QC protocol design, technology/instrumental choice for confidently solving challenges in different assays, the high annotation capacity of GC-MS, and automated data processing and visualization.

Learning Outcomes:
Attendees will gain a broader understanding of the key attributes to consider in successfully non-targeted volatilomics research. Everything form experimental design and QA/QC, to sampling techniques, to routine and advanced sample analysis techniques, and finally data processing and statistical analysis strategies, will be covered.

Видео 2025-W4: Volatilomics - bringing small molecules in multi-omics landscape -biomedical investigations канала Metabolomics Society