Structure and Function of Lymphatic System - Part 1

Structure and Function of Lymphatic System

Prof. Miikka Vikkula, M.D., Ph.D.

Professor of Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium
Center for Vascular Anomalies, Cliniques Universitaires Saint Luc, Brussels, Belgium
Walloon Excellence in Lifesciences and Biotechnology (WELBIO), de Duve Institute, University of Louvain, Brussels, Belgium

The circulatory system consists of two highly-branched tubular structures: the blood vessels and the lymphatic vessels. These systems are essential for the transport of fluids, gas, molecules and cells to and from different organs, and for tissue fluid homeostasis.

The lymphatic system consists of lymphatic vessels and lymphatic organs, such as lymph nodes, tonsils and Peyer’s patches. The lymphatic vessels form a blind-ended one-way closed circuit that acts as a drainage system to collect fluid, cells, and plasma proteins from tissues to return them back to the blood circulation. It has an essential role in the maintenance of fluid homeostasis, as well as immune surveillance and fat adsorption.

The main processes through which the lymphatic network is developed is called lymphangiogenesis. The first theory for venous origin of the lymphatic vasculature was suggested a century ago by Florence Sabin. With the advent of lymphatic markers, our understanding of the precise manner by which the lymphatic system develops has increased importantly. Studies of murine models presenting lymphatic vascular defects have identified several genes implicated in the development of the lymphatic vascular system. This has also shed light into the pathogenesis of lymphatic disorders.

Видео Structure and Function of Lymphatic System - Part 1 канала Lymphangiomatosis & Gorham's Disease Alliance (LGDA)