Metformin excretion

📍Metformin is primarily eliminated unchanged through the kidneys, with about 90% eliminated within 24 hours.

📍 Active tubular secretion by organic cation transporters exceeds glomerular filtration rate, explaining metformin’s renal clearance.

📍 Metformin may accumulate in patients with impaired renal function, necessitating dose adjustments or contraindication in severely reduced kidney function to prevent lactic acidosis.

Видео Metformin excretion канала Simplify_drugs