12 COVID 19 Autopsy Cases Reveal the TRUTH How COVID 19 Patients Dying - Doctor Explains

12 COVID 19 Autopsy Cases Reveal the TRUTH How COVID 19 Patients Dying - Doctor Explains

In all 12 COVID 19 Autopsy cases, the cause of death was found within the lungs or the pulmonary vascular system. Those who did not die of large pulmonary emboli died of extensive inflammation, meaning pneumonia with ARDS. In these COVID 19 Autopsy cases, the lungs were wet and heavy, much like a saturated water sponge. The lung surfaces often had a distinct patchy pattern, with pale areas alternating with slightly protruding and firm, deep reddish-blue Hypercapillarized areas. This indicates areas of intense inflammation, with endothelial dysfunction that can be seen at the microscopic level. When they look at the lungs' slices under the microscope, they found diffuse alveolar damage in 8 COVID 19 Autopsy cases. Specifically, they saw hyaline membrane formation, tiny clots in the capillaries, capillaries engorged with red blood cells, and other inflammatory findings. All these findings represent ARDS. They also found lymphocytes, a type of white blood cell, infiltrated these areas of infiltration. This fits the picture of viral pathogenesis.

⏩ Timestamps, click to skip ahead: 12 COVID 19 Autopsy Cases Reveal!
00:00 - Introduction
02:38 - The starting point of the COVID 19 Autopsy Analysis
04:10 - Why we get COVID 19 false Negative Test
04:34 - Rest of the Part of COVID 19 Autopsy Analysis
09:45 - Big Takeaway's from the Findings in this COVID 19 Autopsy Study
12:30 - Minimize the chances of having the severe disease if you were to get COVID 19

This is the link to the main study in this video:
https://www.acpjournals.org/doi/10.7326/M20-2003

They also looked at the pharynx of these COVID 19 patients, meaning in their throat. The lining of the throat, or mucosa, was hyperemic, meaning very red and irritated. At the microscopic level, they saw lymphocytes invading there, which is consistent with a viral infection. In one COVID 19 case, a COVID 19 patient had lymphocytes invade his heart muscle, findings that are consistent with what we call viral myocarditis. More than half of the COVID 19 patients in this study had large blood clots. One-third of the COVID 19 patients had pulmonary embolism as the direct cause of death. All the others died of intense inflammation in their lungs related to pneumonia with ARDS (Acute Respiratory Distress Syndrome). Recently, studies show that about 1/3rd of COVID 19 patients with severe COVID 19 have blood clots. In another study of 191 COVID 19 patients, half of those who died had clots, compared with 7% of survivors. And levels of D-dimer that were greater than 1000 µg/L were associated with a fatal outcome. So it's pretty clear now that the COVID 19 has caused many clots to form in moderate to severe COVID 19 disease.

How is this happening?
It's likely a combination of reasons that have to do with downregulation of the ACE2 receptor in the lung alveoli, with a subsequent shift towards having more angiotensin II in the lungs, and less angiotensin 1-7 and 1-9 in the lungs, and when this happens, this leads to more cytokine storm with more inflammation, more constriction of pulmonary arteries, and more clots that develop. That, in turn, leads to more endothelial dysfunction in the capillaries that surround the alveoli. Also, there is evidence that the virus attaches to the ACE2 receptors of those endothelial cells that line those capillaries, which further propagates inflammation and clotting. And in the cytokine storm that develops there, RANTES, a chemokine, binds to the CCR5 receptor of CD4 and CD8 lymphocytes, and that causes those lymphocytes to infiltrate those areas of inflammation, and in doing so, further contributes towards the inflammatory reaction. This is why we are seeing low levels of CD4 and CD8 lymphocytes in severe COVID 19. Endothelial damage can also lead to the development of antiphospholipid antibodies, and these antibodies are bad because they trigger blood clots formation. That’s why COVID 19 patients who have clots with antiphospholipid antibody syndrome need to be on blood thinners.

11 out of the 12 COVID 19 patients in this study had underlying heart disease and were obese. These are known risk factors for cardiovascular disease and known risk factors for endothelial dysfunction and are known risk factors for COVID 19. So the big takeaways from the findings in this study are that most people who die of COVID 19 are primarily lung problems. Either related to inflammation with ARDS and/or blood clots.

Antiphospholipid syndrome might be a commonality among patients with thrombosis in COVID 19 patients.

Doctor Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine
Website: https://doctormikehansen.com/
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#covid #covid19 #autopsy

Видео 12 COVID 19 Autopsy Cases Reveal the TRUTH How COVID 19 Patients Dying - Doctor Explains канала Doctor Mike Hansen