ECMO Anticoagulation and Thrombosis by C. VanderPluym | OPENPediatrics

In this World Shared Practice Forum podcast, Dr. Christina VanderPluym, Co-Director of the Stroke and Cerebral Vascular Center and Medical Director of the Cardiac Anti-thrombosis Management and Monitoring Program at Boston Children’s Hospital, discusses emerging concepts in managing anticoagulation of extracorporeal support devices, with a focus on reducing complications such as hemorrhage and thrombosis. She shares her views on the therapeutic offerings currently available for anticoagulation in pediatric mechanical circulatory support, as well as insights into her own clinical practice, along with encouraging data from the pediatric ventricular assist device population.

After this podcast, listeners will be able to:
-Describe the current state of anticoagulation therapy and monitoring in pediatric extracorporeal support
-Compare the advantages and limitations of heparin and bivalirudin for pediatric anticoagulation
-Identify areas of future promise in the field of pediatric anticoagulation for extracorporeal devices

Publication date: September 23, 2022.

Articles referenced:
• Ghbeis, M. B., Vander Pluym, C. J., & Thiagarajan, R. R. (2021). Hemostatic Challenges in Pediatric Critical Care Medicine-Hemostatic Balance in VAD. Frontiers in pediatrics, 9, 625632. https://doi.org/10.3389/fped.2021.625632
• VanderPluym CJ, Cantor RS, Machado D, et al. Utilization and Outcomes of Children Treated with Direct Thrombin Inhibitors on Paracorporeal Ventricular Assist Device Support. ASAIO J. 2020;66(8):939-945. doi:10.1097/MAT.0000000000001093 (13:45)
• https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fda-drug-safety-communication-update-follow-public-health-alert-about-changes-heparin-sodium-usp (18:05)
• Thompson K, Alred J, Deyo A, Sievert AN, Sistino JJ. Effect of New Heparin Potency on Activated Clotting Time during Pediatric Cardiac Surgery: A Retrospective Chart Review. J Extra Corpor Technol. 2014;46(3):224-228. (18:20)

Additional resources:
• www.actionlearningnetwork.org (26:49)

Citation: VanderPluym C, Daniel D, Burns JP. ECMO Anticoagulation and Thrombosis. 9/2022. Online Podcast. OPENPediatrics. https://youtu.be/y4f8NiDJp0g.

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