Update, Wed 16 Dec
Download my two educational text books for free using this link: http://159.69.48.3
Includes option for mobile phone friendly version
Hard copy of the Physiology Notes text book on e bay, https://www.ebay.co.uk/itm/-/15402036...
John’s research on text book efficacy, https://journals.sagepub.com/doi/full/10.1177/2158244015612517
UK
Christmas rules
Germany
Deaths, + 935
Schools
Non-essential businesses
until 10 January
One household, four close family members
France
Curfew
Bars and restaurants closed until 20 January
Spain
https://www.theguardian.com/world/live/2020/dec/15/coronavirus-live-news-netherlands-announces-five-week-lockdown-as-uk-detects-new-covid-strain
10% antibody study shows
N = 51,400
Second half of November
Raquel Yotti, Carlos III health institute
One in 10 people living in Spain would have been infected ... half during the first wave and the other half during this second epidemic wave
Madrid, 18.6%
Previous results of the study - published in July after testing nearly 70,000 people in
April-June, prevalence 5.2 %.
Deaths, + 388 = 48,401
Positive test results, + 10,328 = 1,762,212
Population = 47 million
Cases, 4.7 million
CFR = 2.7%
IFR = 1.02%
Moderna / NIH
Food and Drug Administration scientists
https://www.fda.gov/media/144434/download
54 page document
Two-shot regimen was highly effective, 94%
Prevents infections and symptoms
No serious safety concerns
Friday, 18th
General Gustave Perna
Cambridge, Massachusetts, "vast majority"
Preparing to ship almost 6 million doses
3,285 locations in the first week
US, 20 million then 200 million
It will be a very similar cadence that was executed this week with Pfizer, where we’re hitting initial sites on Monday, follow on Tuesday and Wednesday
Canada, 168,000 this year, 56 million by March
UK, 7 million
European Union, 80m + 80m
Japan, 50m
South Korea, 20m
Switzerland, 7.5m
Vaccine progress
MHRA, 1
137,000 in first week
FDA, 2
HC, 1
EMA, 0
Second peer reviewed vaccine study
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
https://www.nejm.org/doi/full/10.1056/NEJMoa2034577?query=featured_home
Ongoing multinational
Placebo-controlled, observer-blinded, randomised, efficacy trial
16 years or older
One to one
Two doses, 21 days apart
Placebo or the BNT162b2 vaccine
30 μg per dose
Lipid nanoparticle
Modified RNA vaccine
Encodes a membrane-anchored SARS-CoV-2 full-length spike protein
n = 43,448 received injections
BNT162b2 group, n = 21,720
8 cases of COVID, at least 7 days after the second dose
1 severe
Placebo group, n = 21,782
162 cases
9 severe
95% (90.3 to 97.6)
October 9
N = 37,706 with at least 2 months of safety data
49% were female,
83% were white,
9% were Black or African American,
28% were Hispanic or Latino
35% were obese, of at least 30.0
21% had at least one coexisting condition
Median age, 52 years
42% older than 55 years
Safety profile
Short-term, mild-to-moderate pain at the injection site, fatigue, and headache
Safety over a median of 2 months was similar to that of other viral vaccines.
Systemic events, most common after 2nd dose
Resolved after 1 – 2 days
Fatigue and headache, 55%
Placebo fatigue and headache, 23%
Fever, mostly after 2nd dose
Temperature, equal or greater than 38°C
16% of younger recipients
11% of older recipients
Incidence of serious adverse events was low and was similar in the vaccine and placebo groups
No stopping rules were met
Видео Update, Wed 16 Dec канала Dr. John Campbell
Includes option for mobile phone friendly version
Hard copy of the Physiology Notes text book on e bay, https://www.ebay.co.uk/itm/-/15402036...
John’s research on text book efficacy, https://journals.sagepub.com/doi/full/10.1177/2158244015612517
UK
Christmas rules
Germany
Deaths, + 935
Schools
Non-essential businesses
until 10 January
One household, four close family members
France
Curfew
Bars and restaurants closed until 20 January
Spain
https://www.theguardian.com/world/live/2020/dec/15/coronavirus-live-news-netherlands-announces-five-week-lockdown-as-uk-detects-new-covid-strain
10% antibody study shows
N = 51,400
Second half of November
Raquel Yotti, Carlos III health institute
One in 10 people living in Spain would have been infected ... half during the first wave and the other half during this second epidemic wave
Madrid, 18.6%
Previous results of the study - published in July after testing nearly 70,000 people in
April-June, prevalence 5.2 %.
Deaths, + 388 = 48,401
Positive test results, + 10,328 = 1,762,212
Population = 47 million
Cases, 4.7 million
CFR = 2.7%
IFR = 1.02%
Moderna / NIH
Food and Drug Administration scientists
https://www.fda.gov/media/144434/download
54 page document
Two-shot regimen was highly effective, 94%
Prevents infections and symptoms
No serious safety concerns
Friday, 18th
General Gustave Perna
Cambridge, Massachusetts, "vast majority"
Preparing to ship almost 6 million doses
3,285 locations in the first week
US, 20 million then 200 million
It will be a very similar cadence that was executed this week with Pfizer, where we’re hitting initial sites on Monday, follow on Tuesday and Wednesday
Canada, 168,000 this year, 56 million by March
UK, 7 million
European Union, 80m + 80m
Japan, 50m
South Korea, 20m
Switzerland, 7.5m
Vaccine progress
MHRA, 1
137,000 in first week
FDA, 2
HC, 1
EMA, 0
Second peer reviewed vaccine study
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
https://www.nejm.org/doi/full/10.1056/NEJMoa2034577?query=featured_home
Ongoing multinational
Placebo-controlled, observer-blinded, randomised, efficacy trial
16 years or older
One to one
Two doses, 21 days apart
Placebo or the BNT162b2 vaccine
30 μg per dose
Lipid nanoparticle
Modified RNA vaccine
Encodes a membrane-anchored SARS-CoV-2 full-length spike protein
n = 43,448 received injections
BNT162b2 group, n = 21,720
8 cases of COVID, at least 7 days after the second dose
1 severe
Placebo group, n = 21,782
162 cases
9 severe
95% (90.3 to 97.6)
October 9
N = 37,706 with at least 2 months of safety data
49% were female,
83% were white,
9% were Black or African American,
28% were Hispanic or Latino
35% were obese, of at least 30.0
21% had at least one coexisting condition
Median age, 52 years
42% older than 55 years
Safety profile
Short-term, mild-to-moderate pain at the injection site, fatigue, and headache
Safety over a median of 2 months was similar to that of other viral vaccines.
Systemic events, most common after 2nd dose
Resolved after 1 – 2 days
Fatigue and headache, 55%
Placebo fatigue and headache, 23%
Fever, mostly after 2nd dose
Temperature, equal or greater than 38°C
16% of younger recipients
11% of older recipients
Incidence of serious adverse events was low and was similar in the vaccine and placebo groups
No stopping rules were met
Видео Update, Wed 16 Dec канала Dr. John Campbell
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