Pathology | Neoplasia (TP53, Tumor Suppressor, Metastasis) | MBBS 2nd Year/NEET PG/FMGE/INICET

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Pathology | Neoplasia (TP53, Tumor Suppressor, Metastasis) | MBBS 2nd Year/NEET PG/FMGE/INICET

In this comprehensive One Shot lecture, Dr. Ranjith Sir covers the first part of Neoplasia for MBBS 2nd Year students. The session begins with the molecular hallmarks of cancer, explaining the role of proto-oncogenes and tumor suppressor genes like p53 and Rb. Dr. Ranjith Sir details the mechanisms of cancer spread, including the steps of metastasis and routes like lymphatic and hematogenous spread.

Topics Covered:
- Definition and classification of neoplasia
- Molecular hallmarks of cancer
- Proto-oncogenes (RAS, MYC, HER2/neu) and their mutations
- Tumor Suppressor Genes (Rb, p53, APC, BRCA)
- Knudson’s Two-Hit Hypothesis
- Evasion of the immune system by tumors
- Steps and routes of Metastasis (EMT, Extravasation)
- Sentinel Lymph Node Biopsy and its importance
- Differences between benign and malignant tumors

00:00 - Intro
04:50 - Molecular Hallmarks of Cancer
11:13 - Proto-Oncogenes and Mutations
25:15 - Tumor Suppressor Genes & Knudson Two-Hit Hypothesis
32:42 - TP53 Gene - Guardian of Genome
39:43 - APC Gene and Familial Adenomatous Polyposis
47:59 - Evasion of Immune Response
58:20 - Definition and Routes of Metastasis
1:04:05 - Sentinel Lymph Node Biopsy
1:16:52 - Steps of Metastasis (Invasion & EMT)
#pathology #finalyearmbbs #anatomy #neetpg ##mbbs2ndyear #pw #medicaleducation
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Видео Pathology | Neoplasia (TP53, Tumor Suppressor, Metastasis) | MBBS 2nd Year/NEET PG/FMGE/INICET канала PW MedEd