Vitamin D, Strong evidence from Israel
that low levels of vitamin D patients do much worse than high levels of vitamin D patients.
Vitamin D deficiency prevalence and cardiovascular risk in Israel
https://pubmed.ncbi.nlm.nih.gov/20955219/
N = 34,874
Vit D levels, women, 22.7 ng mL
Vit D levels, men, 23.2 ng mL
Prevalence of vitamin D deficiency or insufficiency
(vitamin D levels less than 30 ng mL)
Women, 77·5%,
Men, 79·2%
Only little variation when stratified by age
Prevalence of deficiency in Israel, similar to less sunny regions
Two groups
Group with vitamin D less than 15 ng mL
Group with vitamin D levels more than 30 ng mL
less than 0·031 age-adjusted odds ratios for the presence of,
Hypertension
Diabetes mellitus
Dyslipidemia
Obesity
Peripheral vascular disease
Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069
https://www.webmd.com/lung/news/20220208/vitamin-d-deficiency-tied-to-severe-covid
Potential correlation, low vitamin D and increased risk of infection with SARS-CoV-2,
and poorer clinical outcomes
This study examines
Any relationship exists between,
pre-infection serum 25-hydroxyvitamin D (25(OH)D) level,
With disease severity and mortality due to SARS-CoV-2.
April 7th, 2020 and February 4th, 2021
Positive polymerase chain reaction tests for SARS-CoV-2,
searched for historical 25(OH)D levels measured 14 to 730 days prior
Design
Patients admitted were categorized,
disease severity and level of 25(OH)D
Deficient, less than 20 ng/mL (n = 133)
Insufficient, 20 to 30 ng/mL (n = 36)
Adequate, 30 to less than 40 ng/mL (n = 30)
High-normal, 40 ng/mL or greater (n = 40)
Accounted for changes throughout the year
Results
1,176 patients admitted
253 had records of a 25(OH)D level prior to infection
A lower vitamin D status was more common in patients with the severe or critical disease
In patients with severe or critical disease
87.4% had less than 20 ng/mL
In patients with mild or moderate disease
34.3% had Less than 20 ng/mL
P less than 0.001
Patients with vitamin D deficiency (less than 20 ng/mL)
14 times more likely to have severe or critical disease,
Odds ratio 14 (95% confidence interval 4 to 51) p less than 0.001
Mortality, patients with sufficient vitamin D levels
2.3%
Mortality, patients with deficient vitamin D levels
25.6% mortality rate (p less than 0.001)
Conclusions
Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D was associated with increased disease severity and mortality.
Low vitamin D status has been associated with a range of autoimmune, cardiovascular, and infectious diseases
Essential immunologic mediator
Inhibitory effects on pro-inflammatory cytokines,
TNF-alpha and IL-6
Epidemiological risk factors for vitamin D deficiency
Darker skin pigmentation
Low sun exposure
Skin-covering clothes
Sun creams
Diet low in fish and dairy products
An association between low 25-hydroxyvitamin D (25(OH)D) levels and an increased risk of acquiring influenza and respiratory viruses
Meta-analyses of randomized controlled trials, 2007 and 2020
Vitamin D supplementation reduced the risk of acute respiratory infection as compared with placebos
Factors associated with poorer COVID-19 prognoses
Geographic location in northern countries
Older age
Black and minority ethnic groups
Obesity
Preexisting conditions, diabetes and hypertension
these risk factors are also independently associated with vitamin D deficiency
Difficult to ascertain a definitive causative effect of baseline vitamin D status on a clinical presentation during active COVID-19 infection
A cosinor model, to account for the cycles of serum vitamin D values across the seasons
Vitamin D levels below less than 20 ng/mL
Israeli Arabs 64.3%
Israeli non-Arabs 35.7%
Видео Vitamin D, Strong evidence from Israel канала Dr. John Campbell
Vitamin D deficiency prevalence and cardiovascular risk in Israel
https://pubmed.ncbi.nlm.nih.gov/20955219/
N = 34,874
Vit D levels, women, 22.7 ng mL
Vit D levels, men, 23.2 ng mL
Prevalence of vitamin D deficiency or insufficiency
(vitamin D levels less than 30 ng mL)
Women, 77·5%,
Men, 79·2%
Only little variation when stratified by age
Prevalence of deficiency in Israel, similar to less sunny regions
Two groups
Group with vitamin D less than 15 ng mL
Group with vitamin D levels more than 30 ng mL
less than 0·031 age-adjusted odds ratios for the presence of,
Hypertension
Diabetes mellitus
Dyslipidemia
Obesity
Peripheral vascular disease
Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069
https://www.webmd.com/lung/news/20220208/vitamin-d-deficiency-tied-to-severe-covid
Potential correlation, low vitamin D and increased risk of infection with SARS-CoV-2,
and poorer clinical outcomes
This study examines
Any relationship exists between,
pre-infection serum 25-hydroxyvitamin D (25(OH)D) level,
With disease severity and mortality due to SARS-CoV-2.
April 7th, 2020 and February 4th, 2021
Positive polymerase chain reaction tests for SARS-CoV-2,
searched for historical 25(OH)D levels measured 14 to 730 days prior
Design
Patients admitted were categorized,
disease severity and level of 25(OH)D
Deficient, less than 20 ng/mL (n = 133)
Insufficient, 20 to 30 ng/mL (n = 36)
Adequate, 30 to less than 40 ng/mL (n = 30)
High-normal, 40 ng/mL or greater (n = 40)
Accounted for changes throughout the year
Results
1,176 patients admitted
253 had records of a 25(OH)D level prior to infection
A lower vitamin D status was more common in patients with the severe or critical disease
In patients with severe or critical disease
87.4% had less than 20 ng/mL
In patients with mild or moderate disease
34.3% had Less than 20 ng/mL
P less than 0.001
Patients with vitamin D deficiency (less than 20 ng/mL)
14 times more likely to have severe or critical disease,
Odds ratio 14 (95% confidence interval 4 to 51) p less than 0.001
Mortality, patients with sufficient vitamin D levels
2.3%
Mortality, patients with deficient vitamin D levels
25.6% mortality rate (p less than 0.001)
Conclusions
Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D was associated with increased disease severity and mortality.
Low vitamin D status has been associated with a range of autoimmune, cardiovascular, and infectious diseases
Essential immunologic mediator
Inhibitory effects on pro-inflammatory cytokines,
TNF-alpha and IL-6
Epidemiological risk factors for vitamin D deficiency
Darker skin pigmentation
Low sun exposure
Skin-covering clothes
Sun creams
Diet low in fish and dairy products
An association between low 25-hydroxyvitamin D (25(OH)D) levels and an increased risk of acquiring influenza and respiratory viruses
Meta-analyses of randomized controlled trials, 2007 and 2020
Vitamin D supplementation reduced the risk of acute respiratory infection as compared with placebos
Factors associated with poorer COVID-19 prognoses
Geographic location in northern countries
Older age
Black and minority ethnic groups
Obesity
Preexisting conditions, diabetes and hypertension
these risk factors are also independently associated with vitamin D deficiency
Difficult to ascertain a definitive causative effect of baseline vitamin D status on a clinical presentation during active COVID-19 infection
A cosinor model, to account for the cycles of serum vitamin D values across the seasons
Vitamin D levels below less than 20 ng/mL
Israeli Arabs 64.3%
Israeli non-Arabs 35.7%
Видео Vitamin D, Strong evidence from Israel канала Dr. John Campbell
Показать
Комментарии отсутствуют
Информация о видео
Другие видео канала
NHS ... informationCare home deathsLies and secretsHeart deaths in AustraliaEvidence on covid restrictions now conclusiveWHO’s Global Digital Health Certification NetworkGovernment Counter Disinformation UnitWHO power grabWHO New Health RegulationsCannabidiol and covidVit D and prostate cancerWHO new powers concernNew US Vit D researchVaccine damage, Sir Christopher ChopeTGA document revelationsPost covid myocarditis?Excess deaths, parliament questionsMatt's messagesBird flu in CambodiaViral origins, the stitchupVaccine data from Florida