MIT CompBio Lecture 15 - eQTLs Mediation (Fall 2019)
MIT Computational Biology: Genomes, Networks, Evolution, Health
http://compbio.mit.edu/6.047/
Prof. Manolis Kellis
Full playlist with all videos in order is here: https://www.youtube.com/playlist?list=PLypiXJdtIca6U5uQOCHjP9Op3gpa177fK
All slides from Fall 2019 are here: https://stellar.mit.edu/S/course/6/fa19/6.047/materials.html
Outline for this lecture:
1. Motivations for mapping regulatory variants
2. Ex: Methylation QTLs in Alzheimer’s Disease
3. eQTL conceptual frameworks
4. eQTL discovery: methodologies
5. Insights on eQTL function and biology
- eQTL prevalence and impact
- eQTL positioning
- Reproducibility
- Tissue-specificity
- Gene annotation
- Co-regulation
- Trans-acting eQTL
- Disease-enrichment
- Directionality
- Disease-relevance
6. Allele-specific analysis
7. Mediation analysis & Bayesian inference
Видео MIT CompBio Lecture 15 - eQTLs Mediation (Fall 2019) канала Manolis Kellis
http://compbio.mit.edu/6.047/
Prof. Manolis Kellis
Full playlist with all videos in order is here: https://www.youtube.com/playlist?list=PLypiXJdtIca6U5uQOCHjP9Op3gpa177fK
All slides from Fall 2019 are here: https://stellar.mit.edu/S/course/6/fa19/6.047/materials.html
Outline for this lecture:
1. Motivations for mapping regulatory variants
2. Ex: Methylation QTLs in Alzheimer’s Disease
3. eQTL conceptual frameworks
4. eQTL discovery: methodologies
5. Insights on eQTL function and biology
- eQTL prevalence and impact
- eQTL positioning
- Reproducibility
- Tissue-specificity
- Gene annotation
- Co-regulation
- Trans-acting eQTL
- Disease-enrichment
- Directionality
- Disease-relevance
6. Allele-specific analysis
7. Mediation analysis & Bayesian inference
Видео MIT CompBio Lecture 15 - eQTLs Mediation (Fall 2019) канала Manolis Kellis
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