Analgesic Pathway | Endogenous Opioid System

The body has its own pain relief system that gets activated when experiencing pain.
.
As a painful stimulus ascends to the cerebral cortex (to become consciously aware of the pain) it sends signals to multiple other areas of the brain. This includes:
- Amygdala (emotion)
- Hypothalamus (flight/fight response)
- Reticular formation (arousal and consciousness)
.
1️⃣All of these regions, including the cortex, will send a signal to the
2️⃣Magnus Raphe Nucleus (located at the midline of the medulla) and will
3️⃣Send a serotonergic signal to the spinal cord
4️⃣Stimulate a neuron in the spinal cord that releases Enkaphalin (opioid)
5️⃣Enkephalin will bind to opioid receptors (delta opioid receptors) of both the pre- and post- synaptic pain neuron.
6️⃣Stopping the pain signal!!

Listen to our podcast for more info: https://podcasts.apple.com/au/podcast/dr-matt-and-dr-mikes-medical-podcast/id1270681468

Видео Analgesic Pathway | Endogenous Opioid System канала Dr Matt & Dr Mike