Allen Roses, Barbaresco Pharma, Inc.: GWAS Method for Highly Informative Assoc in Complex Diseases

Speaker: Allen D. Roses, M.D., CEO, Barbaresco Pharmaceuticals, Inc.

A highly polymorphic polyT marker at a single locus [rs10524523] in intron 6 of TOMM40 was found to extend the association of APOE4 to include APOE3 and APOE2. The TOMM40 data are informative for prediction of age of onset of Mild Cognitive Impairment due to Alzheimer’s Disease over the next five years for 97% of Caucasians, based on age and genotype between 65-83 years old. Phylogenetic mapping has facilitated the enrichment of the TOMMorrow clinical trial [Zinfandel-Takeda Alliance] for low dose pioglitazone to delay the onset of MCI. Similar analyses has led to a new faster screens for highly associated markers for other complex diseases, and realistic translation of post-GWAS gene lists.

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