The Human Pangenome

In 2003, biologists created the first ever human genome sequence. The 3 billion DNA letter sequence, called the reference genome, was mostly made up of DNA donated from people in the city of Buffalo, New York. So far, when clinicians and researchers study an individual’s genome, they compare it to the reference genome to identify differences. But can you compare all of humanity to one genome? No, because one reference genome does not convey the genomic diversity of the human species. We need many reference genomes--a pangenome. This monumental undertaking is already taking place and is poised to redefine the future of genomic research and human health. Watch “The Human Pangenome,” a collaboration between The National Human Genome Research Institute and the science media company Massive Science, stemming from a shared belief in showcasing an emerging and vital effort in genomics--one that will impact every one of us.

Further reading:

Advancing the reference sequence of the human genome
https://www.genome.gov/news/news-release/NIH-funds-centers-for-advancing-sequence-of-human-genome-reference
NHGRI researchers generate complete human X chromosome sequence
https://www.genome.gov/news/news-release/NHGRI-researchers-generate-complete-human-x-chromosome-sequence

A co-production of Massive Science (http://www.massivesci.com) and NIH/NHGRI (http://www.genome.gov).

Presented by the National Human Genome Research Institute http://www.genome.gov
Direction and Animation by Rosanna Wan http://www.rosanna-wan.com
Narration by Dr. Shawntel Okonkwo http://www.shawntelokonkwo.com
Sound + Music by Skillbard http://www.skillbard.com
Script by Harriet Bailey and Prabarna Ganguly
Producer Harriet Bailey http://www.harriet-bailey.com
Senior Producer Nadja Oertelt http://www.nadjaoertelt.com
Executive Producer Prabarna Ganguly http://www.prabarnaganguly.com
Produced for and supported by the National Human Genome Research Institute

Видео The Human Pangenome канала National Human Genome Research Institute