Волчаночный антикоагулянт и терапия антикоагулянтами. Разбор клинических случаев.

В рамках видеоурока Вы узнаете об особенностях определения волчаночного антикоагулянта и интерпретация результатов на фоне терапии антикоагулянтами.

Для подготовки видеолекции использовались следующие научные материалы:
1. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite anti- phospholipid syndrome (APS). J Thromb Haemost 2006; 4:295–306.
2. Keeling D, Mackie I, Moore GW, Greer IA, Greaves M; British Committee for Standards in Haematology. Guidelines on the investigation and management of antiphospholipid syndrome. Br J Haematol 2012; 157:47–58.
3. CLSI. Laboratory testing for the lupus anticoagulant; approved guide. CLSI document H60-A. Wayne, PA: Clinical and Laboratory Standards Institute; 2014.
4. Pengo V, Tripodi A, Reber G, et al. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost 2009; 7:1737–40.
5. Moore GW. Recent guidelines and recommendations for laboratory detection of lupus anticoagulants. Semin Thromb Hemost 2014; 40:163–71.
6. CLSI. Collection, Transport, and Processing of Blood Specimens for Testing Plasma‐Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline. CLSI document H21‐A5. Wayne, PA: Clinical and Laboratory Standards Institute, 2008.
7. CLSI. document; Defining, establishing and verifying reference intervals in the clinical laboratory; Approved Guideline. CLSI document C28-A3. Wayne, PA: Clinical and Laboratory Standards Institute, 2008.
8. Moore GW, Kumano. Lupus anticoagulant assay cut-offs vary between reagents even when derived from a common set of normal donor plasmas. J Thromb Haemost, 2019. Oct 30.
9. Gardiner C, Mackie IJ, Malia RG, Jones DW, Winter M, Leeming D, Taberner DA, Machin SJ, Greaves M. The importance of locally derived reference ranges and standardized calculation of dilute Russell's viper venom time results in screening for lupus anticoagulant. Br J Haematol 2000; 111: 1230-1235
10. Tripodi A, Chantarangkul V, Cini M, Devreese K, Dlott JS, Giacomello R, Gray E, Legnani C, Martinuzzo ME, Pradella P, Siegemund A, Subramanian S, Suchon P, Testa S. Variability of cut-off values for the detection of lupus anticoagulants. Results of an international multicenter multiplatform study. J Thromb Haemost 2017; 15: 1180-1190

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