ME/CFS Getting Worse Despite Pacing? Watch this! #MECFS #InsulinResistance #NAFLD

🐙 Baseline decline regardless of how well your pacing is an issue almost all patients with ME/CFS will experience.

If this is something you are struggling with, ask your doctor to order the following 3 sets of fasted blood tests:

1. Insulin HOMA IR & C-peptide.
2. HbA1C & glucose
3. Liver function & CRP

The HOMA IR calculation will determine if you have insulin resistance (IR) as an underlying cause of your ME/CFS baseline decline. This is a ratio of Insulin to glucose in the blood. C-peptide is a measure of pancreas production of insulin. In moderate-severe cases, C-peptide and insulin are elevated even if glucose is normal.

HbA1C is done to rule out diabetes as a cause of IR. It is worth noting that iron deficiency anemia (very common in ME/CFS and insulin resistance) can mask elevated HbA1C to appear as normal.

Liver function tests will determine if there is already established Liver dysfunction. CRP will assess systemic inflammation.

As a severe patient with severe IR, all my blood tests (apart from fasting glucose and liver function) come back abnormal. However, you can have normal blood test results and still get diagnosed with IR as HOMA IR is a ratio calculation. IR will also increases your risk of developing non-alcoholic fatty liver disease (NAFLD). Even though my liver function tests have always been normal, I was diagnosed with NAFLD via ultrasound.

In 2024 I started seeing a private integrative specialist who diagnosed my severe IR and started me on metformin to reverse it. After 3 months my decline stopped and my baseline stabilized in the severe category.

5 months later the 2025 UK biobank study reported the biomarkers consistently found in ME/CFS samples indicated chronic inflammation, IR, and liver disease (PMID: 40537675). It finally clicked why starting on treatment for my insulin resistance improved my ME/CFS symptoms. ME/CFS was causing my IR, which worsens ATP energy production substantially, and predisposes NAFLD liver disease.

Interested in finding out more? Head to my Instagram profile story highlights and look through the one labeled Insulin & NAFLD.

#mecfs #longcovid #myalgicencephalomyelitis #insulinResistance #NAFLD

Видео ME/CFS Getting Worse Despite Pacing? Watch this! #MECFS #InsulinResistance #NAFLD канала Quella the dizzy 🐙 ME & LC Education & Advocacy