Plasmodium Proliferation in Human Erythrocytes: How, Why, and Who?

Presented By: Markus Ganter, PhD

Speaker Biography: Dr. Markus Ganter is a research group leader at the Center for Infectious Disease of Heidelberg University Hospital, Germany. His research focused on the malaria-causing parasite Plasmodium falciparum. Projects in the Ganter lab combine advanced live-cell imaging, genetic and proteomic approaches, as well as modelling to study the unusual cell cycle of Plasmodium falciparum. His work has helped to define mode of parasite proliferation and identified its molecular regulators, with the ultimate goal to translate a molecular understanding of the parasite’s basic biology into novel intervention strategies to curb malaria.

Webinar: Plasmodium Proliferation in Human Erythrocytes: How, Why, and Who?

Webinar Abstract: Malaria is a life-threatening disease that is caused by unicellular eukaryotic parasites of the genus Plasmodium, with P. falciparum being responsible for the most severe form of human malaria. In the clinically relevant blood stage of infection, the parasite proliferates inside erythrocytes via an unusual cell cycle called schizogony. A hallmark of schizogony is the presence of multinucleated cells where the nuclei divide asynchronously despite residing in a common cytoplasm. To investigate the mechanistic basis of schizogony and its molecular determinants, we combine long-term live-cell imaging, genetic, and proteomic approaches as well as mathematical modelling. Our recent work determined how DNA replication and nuclear division are integrated during schizogony and we quantified the dynamics of nuclear multiplication throughout schizogony. This indicates that asynchronous nuclear cycles in the multinucleated schizont facilitate rapid P. falciparum proliferation. We also provide evidence that in P. falciparum early mitotic events a linked to the onset of S-phase, which may compensate for the absence of canonical cell cycle checkpoints. Together, our work on P. falciparum proliferation can highlight targets for chemotherapeutic intervention to curb malaria.

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