Andrea Califano, COVID-19 Virtual Symposium: April 1, 2020

Andrea Califano, PhD: Targeting Master Regulators of coronavirus infection

Andrea Califano has generated algorithms to identify master regulators that ultimately determine a cell’s transcriptional profile and undergo dynamic changes in the context of disease. With the use of these algorithms, drug targets and therapeutics have been evaluated in various diseases for their ability to these reverse pathogenic changes in master regulators.

Using computational analysis, Dr. Califano has found that infection of cells with the SARS-CoV virus results in transcriptional changes similar to what is seen in cancer cells undergoing transformation.

Based on these profiles, several drugs either approved or late-stage in the approval process have been identified that can reverse the SARS-CoV infection signature, potentially inhibiting pathogenesis.

Видео Andrea Califano, COVID-19 Virtual Symposium: April 1, 2020 канала Columbia University's Zuckerman Institute